References: Hair growth and hair loss
Acta Physiol Pharmacol Bulg. 1996;22(2):51-61.
Teratopharmacological and behavioral effects of coffee in mice.
Ajarem JS, Ahmad M.
Department of Zoology, College of Science, King Saud University, Saudi Arabia.
The possible relationship between coffee exposure during pregnancy and the teratopharmacological effects on the developing neonates was evaluated in albino mice. The body weight of pups of treated dams was significantly affected after birth and as the pups grew, their weight gains were lower compared to controls. This effect was time- and dose-dependent and the perinatal treatment was more effective (F(6) = 5.06, p < 0.02) than the prepartum treatment (F(6) = 3.12, p < 0.05). Body hair appearance and eye opening were delayed in all treated groups and again, the perinatal treatment was more effective and dose-dependent. Almost all indices for "locomotor behavior" were affected by all doses of coffee but only in the perinatally treated groups and the effects were neither time- nor dose-dependent. In the "tube restraint test", the latency to the first bite was decreased and the number of bites was increased in the offspring, while in female offspring the effect was opposite. The body weight of female offspring remained low even in young adult animals (F(6) = 9.89, p < 0.005). The brain weight in males was unaffected but in females it was decreased but only at the dose of 2 mg/kg. The liver and kidney weights of both sexes decreased at the lower doses. The protein content of these organs was also significantly affected by coffee treatment. These results suggest that coffee intake during pregnancy should be limited since it produces significant and long-lasting teratopharmacological and behavioral alterations in the offspring.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9465968&dopt=Abstract
JAMA. 1976 May 31;235(22):2396-8.
Trace elements in sickle cell disease.
Prasad AS, Ortega J, Brewer GJ, Oberleas D, Schoomaker EB.
Trace elements in 84 adult patients (38 men and 46 women) with sickle cell disease (SCD) were reflected in clinical and biochemical data. Height was retarded in six men and five women. Eighty percent of the SCD patients in this sample were below the 50th percentile from the normal mean for weight. Twenty-eight men showed a lack of facial and body hair, and five additional subjects showed only scanty facial hair. Whereas zinc in plasma, red blood cells, and hair was decreased, the excretion of zinc in urine was increased in SCD patients as compared to the controls. We believe that one of the mechanisms accounting for zinc deficiency in SCD may be hyperzincuria and that growth retardation and hypogonadism in men so commonly seen in SCD may be related to zinc deficiency.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=946645&dopt=Abstract
Eur Neuropsychopharmacol. 1999 Mar;9(3):239-45.
Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam.
Drago F, Di Leo F, Giardina L.
Institute of Pharmacology, University of Catania Medical School, Italy.
Prenatal stress may induce intrauterine growth retardation, but it is not known whether a treatment with the anxiolytic benzodiazepine, diazepam may interfere with this phenomenon. A daily physical stress consisting of a forced immersion for 15 min in cold water was applied to pregnant rats of the Wistar strain from gestational day 5 until parturition. Animals were treated either with physiological saline or with diazepam (0.1 or 1 mg/kg/day) injected intraperitoneally 1 h prior to stress application. Control animals received injections of physiological saline but were not subjected to physical stress. Newborn pups subjected to prenatal stress showed reduced body weight as compared to control animals. Offspring were also examined for the appearance day of the following reflexes: cliff aversion, startle, righting, forelimb placing, forelimb grasping and bar holding. Hair growth, and first day of ears and eyes opening was also scored. At 60 days of age, male rats from the three experimental groups were subjected to behavioural tests, i.e., constrained swim (despair test) and step-through passive avoidance response. Animals subjected to prenatal stress showed a delayed appearance of all neonatal reflexes and behavioural deficits in adulthood, namely increased immobility in the despair test and reduced retention of a passive avoidance task. The prenatal treatment with diazepam totally counteracted the effect of stress, normalizing the time-course of neonatal reflexes and the behavioural responses in adulthood. No difference was seen between the effects of the two drug doses. It is concluded that prenatal physical stress may induce body growth retardation and may be considered as a model for human intrauterine growth retardation. The treatment with an anxiolytic benzodiazepine, such as diazepam, may counteract the effects of prenatal stress interfering with the biological consequences of stress concerning probably cerebral neurotransmitters in both the unborn foetus and the pregnant rat.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10208294&dopt=Abstract
Buy Lipitor Online
Herbs and Pharmaceuticals Online ||
Hair Million herbal formula for hair loss and hair growth ||
Hair growth research references ||