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References: Hair growth and hair loss

Am Ind Hyg Assoc J. 1976 Jun;37(6):357-60.
The effect of aerosol hair spray inhalation in the hamster.

Gupta BN, Drew RT.

Hamsters were exposed to a commercially available aerosol hair spray actuated for a total of 8 minutes over a 4-hour-period, 5 days/week. They were examined after 1, 2, 3, 4, and 6-week exposures, and 2,4 and 8 weeks after a 6-week exposure. There was a significant increase in the lung weight of exposed hamsters at every time point except 8 weeks after the 6-week exposure. Microscopic changes in the lung were characterized by the presence of a few to a moderate number of macrophages and neutrophils in the alveolar lumina. The number of macrophages and neutrophils appeared directly related to the duration of exposure. Lung changes were minimal during the first 2-weeks of exposure, and 8 weeks after the 6-week exposure (recovery period). Pathologic changes in the lungs of hamsters were reversible after cessation of the hair spray inhalation exposure.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=937175&dopt=Abstract

Am J Epidemiol. 1999 Apr 15;149(8):712-6.
Chemical hair treatments and adverse pregnancy outcome among Black women in central North Carolina.

Blackmore-Prince C, Harlow SD, Gargiullo P, Lee MA, Savitz DA.

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Several studies suggest that toxic chemicals in hair products may be absorbed through the scalp in sufficient amounts to increase the risks of adverse health effects in women or their infants. This case-control study of 525 Black women from three counties in North Carolina who had delivered a singleton, liveborn infant examined whether exposure to chemicals used in hair straightening and curling increased the odds that the infant was preterm or low birth weight. Cases consisted of 188 preterm and 156 low birth weight births (for 123 women, their infant was both low birth weight and preterm). Controls were 304 women who delivered term and normal birth weight infants. Women who used a chemical hair straightener at any time during pregnancy or within 3 months prior to conception had an adjusted odds ratios (OR) of 0.7 (95% confidence interval (CI) 0.4-1.1) for preterm birth and 0.6 (95% CI 0.4-1.1) for low birth weight. Exposure to chemical curl products was also not associated with preterm delivery (adjusted OR = 0.9, 95% CI 0.5-1.8) or low birth weight (adjusted OR = 1.0, 95% CI 0.5-1.9). Despite this failure to find an association, continued search for risk factors to which Black women are uniquely exposed is warranted.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10206620&dopt=Abstract

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To investigate androgen effects on the skin pilosebaceous unit, we studied 21 male-to-female transsexuals and 17 female-to-male transsexuals receiving cross-sex hormones. At baseline and after 4, 8, and 12 months, hair growth was evaluated by the Ferriman-Gallwey score; acne by the Leeds classification; hair growth rate, density, and shaft diameter by image analysis; and sebum production by Sebutape. In males, estrogens and antiandrogens reduced plasma testosterone to below 1.0 nmol/L. Though all parameters of hair growth and sebum production declined, facial hair growth continued. After 4 months, the decrease in shaft diameter had reached its maximum and seemed inversely associated with changes in hair growth length and density. In females, testosterone increased hair growth rate and sebum production. After 12 months, hairs on the cheek and abdomen had not yet reached diameters found in males. 5alpha-Androstane-3alpha,17beta-diol glucuronide levels were only weakly associated with hair growth and sebum production. In conclusion, administration of estrogens and antiandrogens affects length and diameter of hairs at different rates. In the virtual absence of androgens, hair growth continues but at a slower rate. In women, after 12 months of androgen administration, hair diameters have not reached values of adult men.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10946903&dopt=Abstract

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