References: Hair growth and hair loss
J Neurosci. 1997 Jun 1;17(11):4398-405.
The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons.
Stucky CL, Koltzenburg M.
Department of Neurology, University of Wurzburg, D-97080 Wurzburg, Germany.
Mice with a targeted deletion of the low-affinity neurotrophin receptor p75 (p75-/-) exhibit a 50% loss of large- and small-diameter sensory neurons in the dorsal root ganglion. Using neurophysiological recording techniques, we now show that p75 is not required for the survival of specific, functionally defined subpopulations of sensory neurons. Rather, p75-/- mice exhibit losses of neurons that subserve nociceptive as well as non-nociceptive functions. The receptive properties of large myelinated afferent fibers were normal in p75-/- mice. However, the receptive properties of subpopulations of afferent fibers with thin myelinated or unmyelinated axons were strikingly impaired in mice lacking p75. Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers and D-hair receptors and normal heat sensitivity in A-fiber nociceptors.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9151756&dopt=Abstract
Kaibogaku Zasshi. 1997 Apr;72(2):141-9.
[Predetermined epilations on the fixed areas of the face and forehead in a Tfm strain of mouse]
[Article in Japanese]
Yamamoto M.
Institute of Functional Anatomy, Yamano College of Aesthetics, Tokyo, Japan.
Many males and females with the bare skin area on their face were frequently observed in the Tfm strain of mouse representing testicular feminization. The predetermined epilation of oral and neighbouring hairs began at about ten months after birth and the subsequent bare skin area persisted for about 1 year to their death, but in some cases became expanded over the forehead. These facts indicate that this strain will be useful as a test animal for the detection if the effects of cosmetics and toiletry goods, medical drugs and so on. Microscopic examination of the epilation process revealed several morphological changes analogous to those in human male pattern baldness. However, in our case, several facts indicating that the androgens may stabilize hair growth, were discussed.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9153966&dopt=Abstract
Exp Neurol. 2000 Aug;164(2):344-50.
Effects of endogenous neurotrophins on sympathetic sprouting in the dorsal root ganglia and allodynia following spinal nerve injury.
Deng YS, Zhong JH, Zhou XF.
Department of Human Physiology, Flinders University of South Australia, Adelaide, 5001, Australia.
Peripheral nerve injury is often complicated by a chronic pain syndrome that is difficult to treat. In animal models of peripheral nerve injury, sympathetic nerve terminals in the dorsal root ganglia (DRG) sprout to form baskets around large diameter neurons, an anatomical change that has been implicated in the induction of neuropathic pain. In the present study, we have investigated whether neurotrophins derived from peripheral sources play any roles in sympathetic sprouting and neuropathic pain in a rat model of peripheral nerve injury. After transection of the left lumbar (L) 5 spinal nerve, antisera specific to neurotrophins were injected intraperitoneally twice a week for 2 weeks. The foot withdrawal response to von Frey hairs was examined on days 1, 3, 7, 10, and 14 postlesion. After completion of behavioral tests, sympathetic sprouting in DRG was examined by tyrosine hydroxylase (TH) immunohistochemistry. The number of TH-immunoreactive (ir) fibers and baskets around large neurons within the lesioned DRG was dramatically increased in the rats treated with control normal sheep serum. Antisera specific to nerve growth factor (NGF), neurotrophin-3 (NT3), and brain-derived neurotrophic factor (BDNF) significantly reduced the sympathetic sprouting and the formation of baskets. L5 spinal nerve lesion induced a significant increase in foot withdrawal responses to von Frey hair stimuli, which was attenuated by treatment of antisera to neurotrophins with a different time sequential. The effect of BDNF antiserum occurred earlier and lasted longer than those of NGF and NT3 antisera. These results implicate that peripherally derived neurotrophins are involved in the induction of sympathetic sprouting and neuropathic pain following peripheral nerve injury. Copyright 2000 Academic Press.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10915573&dopt=Abstract
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