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References: Hair growth and hair loss

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Welfare-related physiological and behavioural responses were studied in farm-bred male blue foxes (Alopex lagopus). Three different-sized cages (80-cm long [CL80], 120-cm long [CL120], and 240-cm long [CL240]; each 105-cm wide x 70-cm high) with wire-mesh floors and one enlarged cage (CL240E) with both wire-mesh floor (240-cm long x 105-cm wide x 70-cm high) and earthen floor (80-cm long x 105-cm wide x 70-cm high) were compared. N = 30 males for each group. The experiments lasted from weaning in July to pelting in December. Statistical analyses were based on the models accounting for litter as a block effect. Breaking strength of tibia was highest for foxes having access to both wire-mesh and ground floors (CL240E). Stress-induced hyperthermia was evident during capture and immobilisation. The highest rectal temperature (mean +/- SEM) was found in CL240E (capture: 39.6 +/- 0.09 degrees C, restraint:40.0 +/- 0.09 degrees C) and the lowest in CL80 (capture: 39.1 +/- 0.09 degrees C, restraint: 39.7 +/- 0.09 degrees C). Likewise, capture time (median; interquartile range) in the home cage was highest in CL240E (29; 18 to 44) and lowest in CL80 (12; 9 to 14). During capture, foxes tended to withdraw to the farthest site within the cage. CL240E foxes typically showed the most fear towards human. The most confident animals were found in CL80. The cortisol:creatinine ratio (median; interquartile range) obtained from circadian urine did not reveal statistically significant differences among CL80 (3. 5; 2.6 to 4.1), CL120 (2.3; 1.5 to 3.8) and CL240 (2.3, 1.5 to 3.7). The earthen flooring complicated the urine sampling and conclusions for CL240E (1.7; 1.2 to 2.2). CL240E foxes were the most active and explorative on both wire-mesh- and ground-floored open-field arenas. Altogether, 53% of furs from CL240E were classified as very dirty. Dirtiness of furs in other test groups was slight. In conclusion, the present results did not reveal an unambiguous superiority of any of the studied cage options for well-being of farmed blue foxes.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10913798&dopt=Abstract

J Invest Dermatol. 1997 May;108(5):784-91.
Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice.

Kiguchi K, Beltran L, Dubowski A, DiGiovanni J.

The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, Smithville 78957, USA.

Wa-1 mutant mice possess a defect in the production of transforming growth factor-alpha (TGF-alpha) that leads to a phenotype characterized by wavy hair and curly whiskers. In light of recent evidence indicating the importance of TGF-alpha in epithelial tumorigenesis, this study characterizes the responsiveness of wa-1 mice to skin tumor promotion by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). The responsiveness of wa-1 mice to TPA was compared with that of SENCAR and C57BL/6 mice, representing mouse lines highly sensitive and resistant to skin tumor promotion, respectively. Wa-1 mice were found to be very resistant to skin tumor promotion by TPA after initiation with 10 nmol DMBA, similar to C57BL/6 mice. TPA failed to induce a dramatic increase in TGF-alpha mRNA and protein in the skin of wa-1 mice, whereas TGF-alpha mRNA and protein were dramatically induced in the skin (both epidermis and dermis) of SENCAR and C57BL/6 mice. TPA treatment dramatically increased mRNA levels of two other EGF receptor ligands, amphiregulin and heparin binding-EGF, however, in the skin of all three mouse lines. Comparison of histologic changes in skin revealed that wa-1 mice exhibited only modest sustained epidermal hyperplasia after multiple treatments with TPA, similar in magnitude to that of C57BL/6 mice and significantly lower than that of SENCAR mice. The current data indicate that wa-1 mice are relatively resistant to TPA promotion. Possible mechanisms for this resistance are discussed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9129233&dopt=Abstract

Vestn Oftalmol. 1997 Jan-Feb;113(1):16-9.
[Surgical treatment of traumatic madarosis]

[Article in Russian]

Kataev MG, Filatova IA.

Traumatic madarosis is a cosmetic and anatomo-functional problem. Besides the repair of the eyelashes proper, the clinical status of the patient requires repair of the carcass of the damaged eyelid in order to prevent lagophthalmos. The technique of transplanting a free hairy graft from the eyebrows is described. The results of treatment were assessed by the following parameters: the flap taking in, thickness and direction of the new lashes growth, and stability of the eyelid. Complete healing of the graft and stability of the eyelid were attained in all the cases. Good thickness of the eyelashes and the ideal direction of their growth were more difficult to achieve. The causes of failures are discussed. Despite the shortcomings, the method of treating traumatic madarosis proved to be effective and is recommended for clinical use.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9133036&dopt=Abstract

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