References: Hair growth and hair loss
J Anim Sci. 1997 Apr;75(4):1092-9.
Prolactin administration to seasonally anestrous mares: reproductive, metabolic, and hair-shedding responses.
Thompson DL Jr, Hoffman R, DePew CL.
Department of Animal Science, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge 70803-4210, USA.
Eight pony mares received 4 mg of recombinant porcine prolactin (rpPRL) daily for 45 d beginning on January 15; eight control mares received vehicle. Reproductive end points and various indicators of metabolism, hair shedding, and thyroid activity were monitored. Prolactin concentrations peaked in mares treated with rpPRL at 94 +/- 19 ng/mL 2 h after injection and were 5.1 +/- 1.7 ng/mL 24 h after injection. Treatment with rpPRL increased (P < .01) hair shedding within 14 d, which peaked at 28 d and then dropped precipitously. Binding of 125I-equine prolactin confirmed that antibodies were present in rpPRL-treated mares by 28 d, thus only data up to that time are included herein. The percentage of mares in estrus after 17 d of treatment was greater (P < .05) for mares treated with rpPRL than for controls, although the average day of estrus onset did not differ (P > .1). The date of first ovulation, determined from plasma progesterone concentrations, was hastened (P < .005) in mares treated with rpPRL (February 6 +/- 3 d) relative to control mares (March 14 +/- 6 d). Concentrations of insulin-like growth factor I and nonesterified fatty acids were not affected (P < .05) over time. There were minor differences between groups in thyroid hormone secretion. Various assessments of glucose and insulin indicated no perturbation (P > .1) due to treatment with rpPRL. We conclude that prolactin mediates the onset of vernal hair shedding in mares and is in some way involved with ovulation.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9110225&dopt=Abstract
dsto.defence.gov.au
We investigated electro-mechanical transduction within the cochlea by comparing masking of the auditory nerve compound action potential (CAP) by acoustical and electrical maskers. Forward-masking of the CAP reflects the response to the masker of the cochlear location tuned to the probe. Electrical stimulation was delivered through bipolar stimulating electrodes within the basal turn of the scala tympani. The growth of masking of high-frequency probes which excite cochlear locations close to the stimulating electrodes was similar for both acoustic and electrical maskers, suggesting a linear transduction of electrical energy to mechanical energy. Exposure to intense acoustic stimulation caused an equal loss of sensitivity to acoustic and electrical maskers. Masking of lower-frequency probes by electrical maskers increased rapidly with masker current, suggesting the direct electrical stimulation of neural elements. This masking was reduced by the administration of strychnine suggesting a contribution by the efferents towards masking of these low-frequency probes.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9112113&dopt=Abstract
Acta Paediatr. 1997 Jan;86(1):10-7.
Self-assessment of sexual maturity by mid-adolescents based on a global question.
Berg-Kelly K, Erdes L.
Department of Pediatrics, Goteborg University, Sweden.
The objective of this research was to investigate the use of a global question for evaluation of body development relative to age-mates in addition to graded statements on sexual maturity (SM) as part of self-reports on pubertal development. In total, 4516 adolescents answered written questions on pubertal development and the global question. They represented a normative Swedish sample. To validate these results, 100 mid-adolescents were asked to answer the statements regarding SM and the global question. This was compared with ratings made by two professional examiners for each young person. The outcome of the population study was evaluated against standard biological timetables and demonstrated adequate agreement. In the validation study, the inter-rater agreement between the professionals was excellent and so were professional ratings against those of the adolescents, with one exception: boys rating of their public hair. The global question alone gave the best agreement on pubertal progress. We can conclude that the global question is a valid tool for evaluation of pubertal development during mid-adolescence in population surveys.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9116410&dopt=Abstract
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