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References: Laxative

temp/constipation-1.matches:po.cwru.edu

Despite the acknowledged favorable side effects profile of selective serotonin reuptake inhibitors (SSRIs), comparative studies have not found significant differences in efficacy between tricyclics (TCAs) such as imipramine and clomipramine, and SSRIs in the treatment of panic disorder. The present study focuses on treatment completers to inform patients who adhere to a recommended course of treatment on the possible differential patterns of improvement and of change in side effects between sertraline and imipramine. From an intent to treat consecutive sample of patients participating in the 24-week open phase protocolized treatment of a long-term controlled maintenance/discontinuation study, 20 imipramine completers and 16 sertraline completers with moderate to severe baseline symptomatology were compared using primarily repeated measures analysis of variance on measures of symptom severity, on 15 side effects systematically elicited using an inventory and on heart rate and weight. The results revealed greater early improvement with imipramine compared to sertraline but no enduring differences beyond week 8 of treatments. Side effects, in particular dry mouth, constipation, tremors, sweating, and cardiovascular complaints increased more in severity and were more frequent and persistent during imipramine than sertraline but, except for the 10 beats/min increase in heart rate, side effects were clinically insignificant at the end of both treatments. Change in sexual complaints and weight did not differ between the treatments. The more favorable side effect profile of SSRIs versus TCAs was demonstrated even in the best case scenario of treatment completers. The more rapid improvement with imipramine needs replication but, tentatively, it may be attributed to the gre

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Surg Endosc. 2003 Dec 29;17(9). [Epub ahead of print]
Laparoscopic management of Chilaiditi's syndrome.

Lohr CE, Nuss MA, McFadden DW, Hogg JP.

Department of Medicine, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, PO BOX 9160, Morgantown, WV 26506, USA.

Chilaiditi's syndrome refers to the symptoms of abdominal pain, distention, vomiting, anorexia, and constipation caused by hepatodiaphragmatic interposition of the intestine. Although patients with this radiographic finding are commonly asymptomatic, presentation with symptoms is rare and accurately refers to this syndrome. There is an increased incidence of Chilaiditi's syndrome among mentally ill adults. Traditionally, Chilaiditi's syndrome is managed medically by discontinuing causative medicines. However, among the mentally ill population whose psychotropic medications precipitate the interposition of the colon, ceasing these psychotropic medications is not an appropriate option. The case presented involves a mentally ill patient with Chilaiditi's syndrome who was successfully managed with laparoscopic colopexy. At follow-up, the patient reported marked improvement of abdominal symptoms.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14973690&dopt=Abstract [PubMed - as supplied by publisher]

temp/constipation-1.matches:

Rev Med Chir Soc Med Nat Iasi. 2002 Oct-Dec;106(4):730-5.
[In Process Citation]

[Article in Romanian]

Toader E, Tarasi I.

Institutul de Sanatate Publica Iasi, Clinica a II-a Medicala Gastroenterologie, Spitalul Clinic Universitar Sf. Spiridon Iasi.

The aim of this study was to evaluate the clinical factors of the patients with CCR histologically confirmed. PATIENTS AND METHODS: In the study group there were included 117 patients (females: 49-41%, males: 68-59%, range: 39-88 years) with CCR confirmed (rectosigmoidoscopy/colonoscopy + biopsy, X-ray) hospitalized in the Second Medical Clinic Gastroenterology during January 2000-May 2001. RESULTS: For 56 (47.86%) patients the principal sign was rectal bleeding, intestinal disorders (diarrhoea--constipation) in 24 (20.51%) patients, anemia in 19 (16.23%) patients and abdominal pain in 18 (15.38%) patients. The time interval between the onset and the diagnosis of CCR was 1 month up to 2.5 years. For 83 patients (71%) was possible surgical treatment and for 34 patients (29%) palliative method. CONCLUSIONS: At diagnosis the clinical data suggested a malignant disease for most of the patients. The delay of diagnosis was associated with advanced staging of the disease, with limiting therapeutic possibilities. Using the screening for CCR may give the possibility for a curative treatment.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14974219&dopt=Abstract [PubMed - in process]

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