References: Hair growth and hair loss
Gan To Kagaku Ryoho. 1988 Nov;15(11):3081-5.
[Prevention of adriamycin-induced alopecia by scalp hypothermia with a deep-frozen Duncool-Cap]
[Article in Japanese]
Konishi Y, Kuroki T.
Dept. of Surgery, Kobe City General Hospital.
In order to prevent Adriamycin (ADM)-induced alopecia, scalp hypothermia with a Duncool-Cap frozen in a freezer at -70 degrees C was carried out. Of the 18 patients studied, one patient given total ADM doses of 240 mg developed alopecia of moderate degree, and another patient treated with ADM at a dose level of 50 mg developed mild alopecia. Alopecia could be almost completely prevented in 10 of the 11 patients given total ADM doses of 100 mg or less, and in 6 of the 7 patients given total doses of 200 mg or more.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3190248&dopt=Abstract
J Am Acad Dermatol. 1988 Nov;19(5 Pt 1):831-6.
The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia.
Futterweit W, Dunaif A, Yeh HC, Kingsley P.
Division of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029.
Endocrine dysfunction was studied in 109 consecutive female patients with moderate to severe alopecia, mostly of a diffuse pattern. The study included an evaluation of associated hirsutism and/or menstrual dysfunction, plasma hormonal measurements, and ultrasonography of the ovaries. A control group of 24 ovulatory, nonhirsute, nonalopecia individuals was also studied. Of the 109 patients, 70 (64.2%) had no clinical evidence of hirsutism or menstrual dysfunction. Two of 44 patients tested with cosyntropin (Cortrosyn) had 21-hydroxylase deficiency, whereas two other patients had hyperprolactinemia caused by pituitary tumors. Hyperandrogenism was defined as an increase in any of the plasma androgens (testosterone, non-sex hormone-binding globulin bound testosterone, dehydroepiandrosterone sulfate, androstenedione, or dihydrotestosterone) and was noted in 42 of the 109 patients studied (38.5%). Of these 42 patients, 11 were ovulatory with no evidence of clinical hirsutism, 13 were ovulatory and hirsute, and 18 had oligomenorrhea or amenorrhea with or without hirsutism with confirmatory evidence of polycystic ovarian disease. Patients with diffuse alopecia may demonstrate hyperandrogenism, even in the absence of hirsutism, oligomenorrhea, or amenorrhea. The most common endocrine disorder in this series of patients with diffuse alopecia was polycystic ovarian disease.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3192772&dopt=Abstract
No To Shinkei. 1988 Oct;40(10):947-52.
[Clinical symptoms and disability of myotonic dystrophy in Japan]
[Article in Japanese]
Matsuoka Y, Saida K, Nishitani H, Takahashi A.
Department of Neurology, Nagoya University School of Medicine, Japan.
We performed the first nationwide survey of myotonic dystrophy (MyD) in Japan. This paper reports the result of analysis of clinical pictures and disability of 670 patients found in this survey. 413 cases (61.6%) were males and 257 (38.4%) were females. Male/female ratio was approximately 1.6. The age of onset was most often in the third or fourth decade. Mean age of onset was 27.7 years in the males and 26.8 years in the females. Eight percent of the cases presented their symptoms before the age of 9 years. These cases were considered to belong to congenital or infantile form of MyD. There were also a few patients who started noticing their symptoms after the age of 60 years. Duration of the illness at the time of examination was approximately 13 years in both sexes. Myotonia was observed in 97.3% of the males and 98.1% of the females. Muscular weakness was seen in 99.0% of the males and 96.5% of the females. Atrophy was present in 93.5% of the males and 88.9% of the females. These data showed that almost all cases had these three major symptoms related to the skeletal muscles. There were 16 cases which lacked myotonia, and most of them belonged to congenital or infantile form of MyD. Cataract was present in more than a half of the patients (54.4% in the males and 52.0% in the females). Mental retardation was observed in 42.4% of the males and 35.9% of the females. Frontal baldness was seen much more frequently in the males (74.6%) than in the females (22.7%). Generally, as the duration of the illness was longer, these clinical symptoms were seen in higher frequency.(ABSTRACT TRUNCATED AT 250 WORDS)
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3196498&dopt=Abstract
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