References: Hair growth and hair loss
Med Hypotheses. 1999 Nov;53(5):447-9.
Association between alopecia and response to aggressive chemotherapy in patients with Hodgkin's disease.
Lishner M, Manor Y, Kitay-Cohen Y, Avishay AE.
Department of Medicine, Meir Hospital Kfar Saba and Sackler Faculty of Medicine, Tel Aviv University, Israel.
The clinical significance and implications of absence of alopecia and/or neutropenia in patients treated with chemotherapy for malignant disease is unknown. We hypothesized that there is a common mechanism of resistance to the effects and the adverse effects of anticancer treatment, which may have clinical implications. To evaluate this hypothesis, we conducted a retrospective analysis of the charts of 17 consecutive patients with Hodgkin's disease who received at least 4 courses of combination chemotherapy (ABVD or MOPP/ABV). Twelve patients underwent complete alopecia while 5 patients retained their hair or had only minimal hair loss. The two groups had similar pretreatment characteristics. Ten (83%) of the patients with alopecia achieved complete remission as compared with 2 (40%) of the patients who retained their hair (P = 0.11). Also, patients without alopecia had fewer episodes of neutropenia (0% vs 33%, P = 0.02), delays of scheduled treatments (0% vs 66%, P = 0.02) or number of courses with dose reductions (20% vs 41%, P = 0.39). These differences shows a clear trend which did not reach statistical significance due to the small number of patients. We suggest that, in intensively treated patients with Hodgkin's disease, the absence of alopecia may predict a poor response to treatment. Also, patients without alopecia probably have fewer episodes of leukopenia, deferral of treatment courses or number of courses with dose reductions. We hypothesize that there is a common mechanism of resistance to cytotoxic agents that may prevent apoptotic death in both normal and malignant cells.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10616048&dopt=Abstract
Z Hautkr. 1988 May 15;63(5):389-90.
[Wigs as medical aids. Selection, care and cost regulation]
[Article in German]
Ehring F, Mays M, Bosenberg H, Kehling M.
Dermatologischen Abteilung der Fachklinik Hornheide, Westfalischen Wilhelms-Universitat Munster.
In a discreet way, wigs not only cover up a disfiguring loss of hair but also chronic and suppurative diseases of the scalp. We especially deal with the problems regarding the choice of such wigs, how they are--if necessary--disinfected, cleaned, and tended, and how the expenses may be settled.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3136603&dopt=Abstract
Z Hautkr. 1979 May 15;54(10):426-9.
[DNCB therapy of alopecia areata]
[Article in German]
Happle R.
Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. During the last two and a half years, 227 patients who suffered, in the majority of cases, from total or subtotal hair loss, were treated by this method. Unilateral application of DNCB induced unilateral regrowth of hair in 88% of these patients. Under continuous treatment of both sides of the head, this initial response was followed by complete regrowth of hair in 78%. The same result could be obtained by application of squaric acid dibutylester, another potent contact allergen. This indicates that the essential mechanism is contact allergy. Possibly, the regrowth of hair is due to the induction of local nonspecific immunosuppression.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=314203&dopt=Abstract
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