References: Hair growth and hair loss
Br J Exp Pathol. 1985 Dec;66(6):655-62.
Alopecia in mice infected with murine cytomegalovirus (MCMV).
Mims CA.
When mouse cytomegalovirus was injected subcutaneously into 4-12 day old CDI mice there was infection of dermal cells and the dermal papillae of hair follicles. Infected cells were never seen in the epidermis nor in the epithelium of hair follicles. When larger doses of virus (5 X 10(4) pfu) were given, dermal infection led to gross necrosis of the skin, ulceration, scabbing and healing with alopecia. Smaller doses (10(4) pfu) did not cause gross necrosis but damage to follicles resulted in alopecia or sparse hair growth. Skin lesions were not seen after infection of 4-8 week old mice, even when the inoculated skin area had been epilated, or when hyaluronidase was mixed with the virus inoculum. These experiments show that cytomegalovirus, in contrast to herpes simplex and varicella-zoster viruses, infects dermal but not epidermal cells, and that dermal tropism is age-restricted.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3002414&dopt=Abstract
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 1):931-7.
[A phase II study of intravenous VP-16-213 in small cell and non-small cell carcinoma of the lung]
[Article in Japanese]
Konno K, Nagahama F, Nakai Y, Nakabayashi T, Hiraga Y, Takebe K, Tamura M, Oizumi K, Sato M, Ito T, et al.
A phase II clinical trial of VP-16-213 was carried out in 71 patients with small cell and non-small cell carcinoma of the lung. Forty-eight evaluable cases consisted of 36 small cell carcinomas, 7 epidermoid carcinomas, 4 adenocarcinomas and one unclassified carcinoma. VP-16-213 was administered by drip infusion at dosages of 60-100mg/m2/day for 5-consecutive days at 3-4 week intervals. Twelve of 36 (33.3%) small cell carcinomas had partial responses, while no responses were obtained in non-small cell carcinomas. Median duration of responses was 46 days (range 31-133 days). The dose limiting toxicity was leukopenia. Median number of days to nadir was 14 days and median numbers of days for recovery was 11 days. Nausea (38%), vomiting (12%), anorexia (45%) and alopecia (74%) were major clinical toxicities although these were mild or reversible. We concluded that VP-16-213 was useful in the treatment of small cell lung cancer and the dose schedule used in this study was recommendable with small dose reduction for further trial of combination chemotherapy.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3008671&dopt=Abstract
Vet Rec. 1999 Nov 6;145(19):542-4.
Studies on the inheritance of hair loss in the Irish water spaniel.
Cerundolo R, Lloyd DH, Pidduck HG.
Department of Small Animal Medicine and Surgery, The Royal Veterinary College, North Mymms, Hatfield.
The inheritance of hair loss in Irish water spaniels has been studied by evaluating the inbreeding levels and genetic relationships in a group of affected and unaffected dogs. A detailed study of the pedigree tree of four families revealed a familial predisposition suggesting a dominant mode of inheritance.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10609570&dopt=Abstract
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