References: Hair growth and hair loss
Dermatologica. 1987;174(5):214-8.
Alopecia areata incognita: a hypothesis.
Rebora A.
To explain why in alopecia areata the hair falls out in a particular area the hypothesis is proposed that the area occurs as a stochastic event only in those subjects who, in a restricted zone of their scalp, happen to have a group of hairs that are simultaneously in the early anagen VI subphase of the hair cycle. Once this point has been accepted, a number of conclusions may be drawn. Especially important is the inference that only people with low percentages of telogen hairs are likely to exhibit areas, whereas those with androgenetic alopecia, when affected by alopecia areata, preferentially show a diffuse and delayed hair loss that has the features of Kligman's telogen effluvium (alopecia areata incognita). Epidemiological evidence is provided.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2953632&dopt=Abstract
Rev Med Liege. 1999 Oct;54(10):829-31.
[How I explore ... vitiligo]
[Article in French]
Hermanns JF, Pierard GE.
Service de Dermatopathologie, Universite de Liege.
Vitiligo is likely a syndrome rather than a disease. Several pathogenic causes are indeed recognized. The exploration of such condition encompasses three distinct facets. Establishing the diagnosis and a precise typing of the skin clinical presentation represents the first step. The ophthalmologic examination is mandatory in order to detect infraclinical signs of uveitis and retinopathy. Auditory problems can also be present. Searching for associated diseases should be oriented in priority toward alopecia areata and some specific autoimmune endocrinopathies.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10605320&dopt=Abstract
Exp Clin Endocrinol. 1987 Aug;90(1):107-12.
Nuclear and cytosol androgen receptor in androgen dependent dermatoses in female patients.
Schmidt JB.
Department of Dermatology II, University of Vienna, Austria.
Determination of cytosol and nuclear androgen receptor (AR) was performed in females with androgen dependent dermatoses. 34 patients with acne, hirsutism and androgenetic alopecia were punch biopsied on day 21 of the menstrual cycle under local anesthesia within correspondent predilection sites. The tissue was snap frozen in liquid nitrogen and stored until receptor assays were performed. Overall evaluation of both, cytosol and/or nuclear AR was positive in 76% of all cases. In 86% of (10 out of 14) females with androgenetic alopecia, in 80% (8 out of 10) of patients with acne and 60% (6 out of 10) of hirsute females cytosol and/or nuclear AR were positive. No significant differences of cytosol androgen receptor levels became evident between the dermatoses. In contrast, nuclear androgen receptor levels showed a trend towards distinct differences with highest levels in hirsutism, followed by androgenetic alopecia and acne. Androgen stimulability thus seems to be superior in the first and minor in the latter. Comparison with previous studies on cytosol androgen receptor in androgen dependent dermatoses shows significantly higher number of positive results by additive nuclear receptor determination. Additional nuclear androgen receptor assay, thus gives a more complete picture of local hormone action.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2959494&dopt=Abstract
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