References: Hair growth and hair loss
J Appl Toxicol. 1989 Feb;9(1):59-65.
An evaluation of the acute toxic properties of liquids derived from oil sands.
Stubblefield WA, McKee RH, Kapp RW Jr, Hinz JP.
Exxon Biomedical Sciences, Inc., East Millstone, NJ 08873.
The acute toxicity of three materials derived from Athabasca Oil Sands--(1) bitumen plus naphtha, (2) untreated naphtha (0-250 degrees C) and (3) synthetic crude oil (0-500 degrees C)--was assessed in a battery of tests. In acute oral studies, all three test materials exhibited a low order of toxicity (LD50 greater than 5.0 g kg-1). The acute dermal LD50 was also low (greater than 3 g kg-1) for each test material. All three materials were judged to be 'slight' ocular irritants. Acute inhalation studies (6-h exposures at the maximum attainable concentrations) produced varied responses. Bitumen plus naphtha administered at a concentration of 1.46 mg l-1 did not cause mortality in exposed rats or mice. Lung discoloration was the only necropsy finding of note. Untreated naphtha administered at a concentration of 10.6 mg l-1 was lethal to essentially all of the mice; but only two rats died. Necropsy findings included elevated weights in the liver and kidneys of the exposed mice, elevated lung weights in male rats and elevated liver weights in female rats. Synthetic crude oil administered at a concentration of (4 mg l-1) was lethal to 5/10 mice, but none of the rats (0/10) died. Severe hair loss was noted in the surviving mice, and slight alopecia was also observed in rats. Both species exhibited elevated liver weight, and elevated lung weight was noted in female rats.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2926098&dopt=Abstract
Gan No Rinsho. 1989 Feb;35(3):371-7.
[Combination chemotherapy using cyclophosphamide, adriamycin, and cisplatin in recurrent or advanced endometrial cancer--a preliminary report]
[Article in Japanese]
Baba S, Kashimura M, Shinohara M, Kusano S, Sasayama T, Hamasaki K.
Dept. of Obstet. & Gyne., School of Med., Univ. of Occupational and Environmental Health.
Four patients with recurrent or advanced endometrial cancer have undergone combination chemotherapy with Cyclophosphamide, Adriamycin and Cisplatin (CAP). All drugs were administered by I.V. on day 1 in the following doses: Cyclophosphamide 500 mg/m2, Adriamycin 50 mg/m2 and Cisplatin 50 mg/m2. The treatment was repeated every 4 weeks and continued as long as there was disease progression. Two complete clinical responses and two partial responses were achieved. Based on these good results, we have initiated post-operative prophylactic chemotherapy using CAP in high risk patients. Adverse effects including myelo-suppression, nausea, and vomiting, and alopecia were seen in almost all patients. In no case, however, did any patient experience life-threatening toxicity. Based on our experience, CAP therapy appears tolerable when used per our schedule.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2926985&dopt=Abstract
Am J Dermatopathol. 1985 Jun;7(3):245-57.
Follicular mucinosis. A reaction pattern in follicular epithelium.
Hempstead RW, Ackerman AB.
Follicular mucinosis is a histologic term for a reaction pattern in follicular epithelium. Although it is the sine qua non for alopecia mucinosa as a disease sui generis, it may occur in a variety of unrelated conditions, which may be inflammatory, hamartomatous, hyperplastic, or neoplastic. Follicular mucinosis is rare in plaque and nodular lesions of mycosis fungoides, but when it occurs, the malignant lymphoma is not related to the condition known as alopecia mucinosa. In short, alopecia mucinosa is a wholly benign condition and is not premonitory or an early aspect of mycosis fungoides. Follicular mucinosis is not synonymous with alopecia mucinosa but is analogous to other histologic reaction patterns of cutaneous epithelium such as epidermolytic hyperkeratosis, focal acantholytic dyskeratosis, and cornoid lamellation.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2932031&dopt=Abstract
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