References: Hair growth and hair loss
Strahlentherapie. 1979 Mar;155(3):165-70.
[Side effects and late results of the combined radio- and chemotherapy of the brain in children with acute lymphoblastic leukemia (author's transl)]
[Article in German]
Zippel RM, Sack H.
In case of lymphoblastic leukemia, acute general side effects of the therapy phase II which occured, mostly in the form of gastric troubles, in 42,0% of the 50 children, have to be attributed to the skull irradiation as well as to the intrathecal MTX injections. Irritations of the meninges provoked in the course of phase II appeared in the form of a liquor pleocytosis in 44,7% of 38 children and in the form of an augmentation of the liquor proteins in 23,6%. Considering the success of the meningiosis prophylaxis, alopecia must be tolerated. In 66,0% of the 50 cases, the syndrome of somnolescence was found two to nine weeks after phase II; this syndrome is considered to be reversible, and no late damages are known until now. A therapy control is possible by periodical neurologic examinations and electroencephalography: after phase II, a normal EEG is found in 66,7% of 39 cases; a pathological EEG is found in 28,2% of the cases with preliminary EEG and in 5,1% of the cases without preliminary EEG. The psychic development of the children submitted to a central nervous system prophylaxis can only be judged in a reliable manner if comparative tests are executed. The irradiation dose to the skull during phase II is within the generally accepted tolerable values; seven children were dissected, and the neurohistologic examinations produced no evidence of late irradiation damages.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=285477&dopt=Abstract
Arch Dermatol Res. 1986;278(3):214-8.
Topical immunotherapy changes the composition of the peribulbar infiltrate in alopecia areata.
Happle R, Klein HM, Macher E.
It has previously been shown that, in patients with untreated progressive alopecia areata (AA), the peribulbar T4/T8 ratio is about 4:1. In the present study, the immunohistochemical findings obtained in untreated AA patients were compared to those obtained in patients who had received topical immunotherapy with diphencyprone. The untreated group consisted of 5 patients with progressive AA and 5 patients with inactive AA. The treated group consisted of 5 patients with a good response to diphencyprone and 5 patients with little or no hair regrowth after treatment. In untreated patients with progressive AA, the mean peribulbar T4/T8 ratio was 4:1, whereas in untreated patients with stable AA, the ratio was 2:1. In the treated patients with a good response to diphencyprone, the mean T4/T8 ratio was 1:1, while in the patients with poor or no response to treatment, the ratio was 0.7. In conclusion, topical immunotherapy considerably alters the peribulbar T4/T8 ratio in AA. The results are consistent with, but do not prove, the concept of topical immunomodulation.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2873796&dopt=Abstract
Int J Fertil. 1987 Jan-Feb;32(1):41-5.
Low-dose spironolactone in the treatment of female hirsutism.
Ylostalo P, Heikkinen J, Kauppila A, Pakarinen A, Jarvinen PA.
Twelve women, 11 with hirsutism and one with alopecia areata, were treated with low-dose spironolactone (50 mg daily) from the 4th until the 22nd cycle day over 12 consecutive menstrual cycles. Eight hirsute women observed a favorable effect on hirsutism in 3 to 8 months, and hair loss ceased in the one patient with alopecia areata. No significant side effects occurred. Low-dose spironolactone decreased the concentration of total and free testosterone and elevated the concentration of prolactin on the 10th cycle day, while LH, FSH, estradiol, progesterone, DHEAS, SHBG, and cortisol levels remained unchanged. The plasma aldosterone concentration increased significantly during the treatment, although serum potassium and sodium concentrations remained unchanged. Low-dose spironolactone is, thus, safe and effective in the treatment of hirsutism. It seems to be useful as an initial or alternative treatment.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2880814&dopt=Abstract
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