References: Hair growth and hair loss
J Am Acad Dermatol. 1985 Jan;12(1 Pt 1):78-84.
Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: association with autoantibodies.
Lowy M, Ledoux-Corbusier M, Achten G, Wybran J.
Twenty patients with alopecia universalis, alopecia semiuniversalis and alopecia areata were studied for their immune parameters. Fourteen of them received an oral treatment with Isoprinosine, a synthetic immunomodulator. Ten patients showed the presence of several autoantibodies. No significant abnormalities in various T cell rosette markers were found, but T4/T8 ratios tended to be elevated. Erythrocyte antibody complement (EAC) rosettes were usually decreased. Treatment with Isoprinosine produced a clinical response, as judged by total or partial hair growth, in nine of the fourteen patients treated. It was striking to observe that seven of the nine responders had autoantibodies prior to treatment. These autoantibodies disappeared or decreased with Isoprinosine therapy. In contrast, only one of five nonresponders had serum autoantibodies. After treatment, both groups showed an increase in blood-active T rosettes. These results suggest that alopecia is a heterogeneous disease subdivided by the presence or absence of autoantibodies since clinical response was mainly obtained in patients presenting autoantibodies.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2579988&dopt=Abstract
J Am Acad Dermatol. 1989 Dec;21(6):1235-40.
Mucocutaneous complications of intraarterial 5-bromodeoxyuridine and radiation.
McCuaig CC, Ellis CN, Greenberg HS, Hegarty TJ, Page MA.
Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI 48109-0314.
5-Bromodeoxyuridine (BUDR), a halopyrimidine thymidine analogue, is incorporated into the DNA of dividing cells and causes photoradiosensitization. Twenty-five patients with malignant astrocytomas were treated with continuous intracarotid BUDR radiosensitization and radiotherapy for 8 1/2 weeks. Unique dose-limiting mucocutaneous complications were encountered. Ipsilateral facial dermatitis with epilation of eyebrows and eyelashes, ocular irritation, and bilateral nail dystrophy developed in all patients. Less common reactions included oral ulceration in six patients, body exanthem on the trunk in five, and atypical erythema multiforme major in one.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2584461&dopt=Abstract
Nippon Hifuka Gakkai Zasshi. 1989 May;99(6):743-5.
[Correlation of activated T cells and natural killer (NK) cells with the disease activity of alopecia areata (AA)]
[Article in Japanese]
Imai R, Miura J, Takamori K.
Patients with AA were classified into one of two types (Type A: active AA with less than 3 patches; Type B: active AA with 10 or more patches). The percentages of activated T cell subsets and NK cell subsets in the peripheral blood of Type A were similar to those of the normal control. On the other hand, the percentages of HLA-DR+ Leu2a+ cells, HLA-DR+ Leu3a+ cells, Leu7+ Leu11+ cells and Leu7- Leu11+ cells in Type B were significantly higher than those of the normal control. These findings suggest that activated T cells and NK cells play an important role in the disease activity of AA.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2585776&dopt=Abstract
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