References: Hair growth and hair loss
Z Hautkr. 1989 Jan 15;64(1):9-12.
[Hypothyroidism and hyperprolactinemia as a possible cause of androgenetic alopecia in the female]
[Article in German]
Schmidt JB, Schurz B, Huber J, Spona J.
II. Universitats-Hautklinik Wien.
31 female patients suffering from androgentic alopecia were examined by means of the TRH test with regard to hypothyroidism and hyperprolactinemia. Before, as well as 20 and 40 minutes after, application of thyroxine releasing hormone (TRH), the serum concentrations of the hypohyseal thyroxine stimulating hormone (TSH) and prolactin (PRL) were measured by radioimmunoassay (RIA). In 7 of the patients (23%), we found increased TSH levels after stimulation with TRH--indicative of hypothyroidism. In 9 of the patients (29%), we observed increased PRL levels after TRH stimulation, indicating prolactinemia. TSH and PRL can interact with androgen metabolism at various levels. Thyroxine may influence the unbound, metabolically active testosterone via the sex hormone binding globulin (SHBG). Prolactine, which is stimulated by TRH, promotes the suprarenal cortisol and androgen production. In 48% of the patients, we found either hypothyroidism or hyperprolactinemia. This suggests that both conditions may contribute to the clinical picture of female androgenetic alopecia, as they interfere with the androgen metabolism.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2494810&dopt=Abstract
Zentralbl Veterinarmed A. 1989 Jul;36(6):447-52.
Pathological studies of cross-related congenital hypotrichosis in cattle.
Ayers JR, Leipold HW, Schalles R, Cole D.
Examination of 13 cattle with cross-related congenital hypotrichosis showed that the disease is characterized by a short, curly, dilute-color, malformed, sometimes sparse, hair coat that occasionally causes physical impairment of the affected animal. Because the disease is associated with crossbreeding programs utilizing certain breeds of cattle, it is hypothesized that the etiology may be due to color dilution mutants present in European breeds of cattle. Continued investigation may lead to a more complete understanding of this disease.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2508373&dopt=Abstract
Stomatologiia (Sofiia). 1989 Jan-Feb;71(1):10-3.
[Melanocytic population of buccal mucosa of patients with lichen planus]
[Article in Bulgarian]
Durmisev A, Balabanova M.
The authors have studied the melanocytic population in oral mucosa (Dihydorxyphenyl alanine, silver impregnation, hematoxilin-eosin) of 20 patients (10 with Lichen ruber planus and 10 with Alopecia areata). The melanocytic population in oral mucosa ranges from 605 to 1555 cells per m2 (964 +/- 312 on the average). Normal population, in case of lichen planus of oral mucosa, is disturbed in the regions of the pathological process. The deviations established are discussed.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2520865&dopt=Abstract
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