References: Hair growth and hair loss
Geburtshilfe Frauenheilkd. 1986 Jul;46(7):439-43.
[Effects of a chlormadinone acetate-containing ovulation inhibitor on androgenization pictures and liver and lipid metabolism in young females]
[Article in German]
Cirkel U, Belkien L, Hanker JP, Schweppe KW, Schneider HP.
Twenty-two patients, average age 22 years, were treated for androgenization phenomena with a combination preparation containing ethinyl estradiol and chlormadinone acetate (Neo-Eunomin) over a period lasting 12 cycles. Under this therapy acne, seborrhea, alopecia and hirsutism improved. The hepatic metabolism parameters checked before and during the study (alkalic phosphatase, SGPT, gamma-GT and total bilirubin) showed no pathologic changes and decreased significantly toward the end of the treatment period. SGOT remained uninfluenced. The effects on the lipoproteins checked were favorable, as the atherogenic index (LDL/HDL) dropped from 2.2 prior to therapy to 1.7 in the twelfth cycle of the treatment period. The HDL fraction increased significantly in the very first cycle, while the LDL fraction remained almost constant. There was a significant increase in cholesterol and triglycerides. The serum androgen count (testosterone and DHEA-S) was significantly lowered. There was a clear decrease in testosterone in saliva.
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Acta Derm Venereol. 1986;66(6):485-90.
Immunohistological evaluation of alopecia areata treated with squaric acid dibutylester (SADBE).
Johansson E, Ranki A, Reunala T, Kianto U, Niemi KM.
A total of 19 patients with alopecia areata volunteered for serial biopsies of the scalp skin during SADBE treatment. Regrowth of terminal hair was seen in 12 of the 19 patients on the side of the scalp treated with SADBE for a minimum of four months, but not on a control side treated with sodium lauryl sulphate (SLS). Immunocompetent cells were characterized with ANAE staining and monoclonal antibodies in biopsy specimen showing marked peribulbar and perivascular inflammatory cell infiltrates. Inflammatory cell subclasses were repeatedly evaluated during SADBE treatment. No specific alterations in lymphocyte subclasses and macrophages were seen in relation to the hair growth response. In immunofluorescent studies it was found that in patients with regrowth of hair, immunoglobulins, fibrin and complement, appeared in the hair bulb and along the basement membrane during the treatment. Results were negative in patients without regrowth of terminal hair and in SLS-treated skin. As we could not demonstrate that any cell-mediated mechanism was involved, we suggest that SADBE may induce terminal hair growth through as yet uncharacterized mediators.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2433867&dopt=Abstract
Acta Derm Venereol. 1986;66(6):532-4.
Serum testosterone and sex hormone binding globulin levels in women with androgenetic alopecia.
Georgala G, Papasotiriou V, Stavropoulos P.
Serum levels of testosterone and sex hormone binding globulin (SHBG) were assessed in eight women suffering from male pattern alopecia. Eight healthy women of similar age served as controls. A statistically non-significant increase was observed in serum testosterone levels as compared with those of the controls (p greater than 0.1). On the other hand, a statistically significant fall was observed in serum SHBG levels as compared with those of the controls (p less than 0.001).
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2433877&dopt=Abstract
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