References: Hair growth and hair loss
Nippon Hifuka Gakkai Zasshi. 1990 Oct;100(11):1143-52.
[Significance of HLA-DR+ T cells and natural killer (NK) cells in the peripheral blood lymphocytes of alopecia areata (AA)]
[Article in Japanese]
Imai R.
Department of Dermatology, Juntendo University School of Medicine.
HLA-DR+ T cell and NK cell subsets in peripheral blood lymphocytes of patients with AA were investigated. The percentages of HLA-DR+ T cell and NK cell subsets from a mild condition of patchy AA and an acute condition of alopecia totalis, for which hair regrowth occurred frequently with ease, were similar to those of the normal control. On the other hand, the percentages of HLA-DR+ Leu3a+ cells HLA-DR+ Leu2a+ cells and Leu7-Leu11+ cells from a severe condition of patchy AA and alopecia universalis, for which hair regrowth did not easily occur, were significantly higher than those of the normal control. The increase in the percentages of HLA-DR+ Leu3a+ cells, HLA-DR+ Leu2a+ cells and Leu7-Leu11+ cells from the severe condition of patchy AA and alopecia universalis was lessened and normalized by treatment with betamethasone. These findings suggest that the auto-immune disorders of HLA-DR+ T cell and NK cell may play important roles in disease activities related to severe patchy AA and alopecia universalis.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2273577&dopt=Abstract
Khirurgiia (Mosk). 1990 Sep;(9):81-5.
[Treatment of cicatricial alopecia by the method of tissue expansion]
[Article in Russian]
Madazimov MM, Grishkevich VM, Moroz VIu, Vaganova NA.
The tissue extension method was applied in 13 patients with cicatricial alopecia of the scalp. Eighteen Soviet-made tissue expanders were used. Clinical experience showed that the sequelae of burns of the scalp attended by alopecia should be treated by tissue extension. The growth of hair can be restored on up to half of the scalp surface by expansion of the local tissues by their direct transfer and by additional formation of grafts for contour plastics. Plastics by expanded tissues is indicated for closure of naked bones of the vault of the skull.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2273857&dopt=Abstract
J Heart Transplant. 1990 Nov-Dec;9(6):668-73; discussion 673-4.
15-Deoxyspergualin and primate heart transplantation.
Kapelanski DP, Perelman MJ, Faber LA, Paez DE, Rose EF, Behrendt DM.
Department of Surgery, University of Iowa College of Medicine, Iowa City.
15-Deoxyspergualin is a synthetic polyamine that exhibits a novel spectrum of immunosuppressive activity in lower mammals. To define the clinical potential of this drug, we performed 25 abdominal heterotopic heart transplants in Macaca fasicularis. Donor and recipient pairs were selected from ABO-identical animals with negative erythrocyte crossmatches. All recipients received one dose of methylprednisolone sodium succinate at graft reperfusion. Five control recipients received no subsequent immunosuppression. Five recipients received high-dose 15-deoxyspergualin (7.5 mg/kg IM). Five recipients received low-dose 15-deoxyspergualin (2.0 mg/kg IM). Five recipients received cyclosporine (1.0 mg/kg IM). Five recipients received both 15-deoxyspergualin (2.0 mg/kg IM) and cyclosporine (1.0 mg/kg IM). Immunosuppressive agents were administered daily, beginning with the morning of operation, and were continued until the animal was killed or 30 days had elapsed. Graft function was assessed by daily palpation. Median graft survival among control recipients was 9 days (range, 6 to 34 days). At the dose used, cyclosporine alone did not influence either graft survival time (median survival, 13 days; range, 7 to 23 days) or rejection grade. Graft survival and rejection grade among recipients treated with low-dose 15-deoxyspergualin were not different from control recipients or those treated with cyclosporine alone (median survival, 10 days; range, 8 to 39 days). One recipient, killed on postoperative day 8, had an intraadominal abscess. In each of the recipients treated with high-dose 15-deoxyspergualin systemic toxicity developed, and the animal was killed when death appeared imminent, although graft contraction remained vigorous (median survival, 28 days; range 25 to 30 days).(ABSTRACT TRUNCATED AT 250 WORDS)
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