References: Hair growth and hair loss
Clin Exp Dermatol. 1991 May;16(3):188-92.
Natural progression of male pattern baldness in young men.
Rushton DH, Ramsay ID, Norris MJ, Gilkes JJ.
School of Pharmacy & Biomedical Sciences, Portsmouth Polytechnic, UK.
Twenty-six men who presented with male pattern baldness (androgen-dependent alopecia), were quantitatively evaluated for scalp hair variables and compared with 13 age-matched controls. Compared to controls, significant mean differences for hair variables were found in the frontal-vertex area, while in the occipital area, a reduction in total hair density (hairs/cm2) was the only significant (P less than 0.05) finding. A large proportion (48.5%) of meaningful hair (non-vellus hair) was less than or equal to 40 mm in length, yet had diameters similar to hairs growing much longer. In controls, these hairs accounted for only 12.2% of the total population. Compared to baseline, mean values from the frontal-vertex area of subjects with androgen-dependent alopecia were significantly lower for total hair density, meaningful hair density (non-vellus hairs/cm2) and percentage of hair in the anagen growth phase, 12 and 24 months later. During this time, total hair density decreased by 6.5% after 12 months and by 11.9% after 24 months. Similarly, meaningful hair density declined at 12 months by 10.8% and by 22.7% after 24 months. No change in any hair variable was detected in controls after 12 or 24 months. Our findings suggest that medications capable of maintaining the existing hair population should be regarded as effective treatments for this condition. Left untreated androgen-dependent alopecia progressively deteriorates. The induction of non-vellus hairs less than or equal to 40 mm in length to grow longer, would substantially improve the aesthetic profile without the need to generate new hair.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1934570&dopt=Abstract
J Hered. 1991 Sep-Oct;82(5):431-4.
Morphological analysis of hair in the hr-2 mutant deer mouse (Peromyscus maniculatus).
Knapp LW, Dawson WD.
Department of Biological Sciences, University of South Carolina, Columbia 29208.
Skin from 36 hairless deer mice (Peromyscus maniculatus) homozygous for the recessive hr-2 mutation were analyzed for structural defects in hair and hair loss. Comparison of mutant to wild-type hairs demonstrated characteristic abnormalities in cellular organization, hair shape, length, and fragility. Matings between mutants homozygous for the hr-2 gene and for a second mutation producing hairlessness in deer mice, hr-1, showed that these two genes were nonallelic. Structural abnormalities in hairs associated with the expression of this gene suggest that its primary effect may be on the epidermis.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1940285&dopt=Abstract
J Rheumatol. 1991 Aug;18(8):1185-6.
Alopecia in systemic lupus erythematosus. Relation to disease manifestations.
Wysenbeek AJ, Leibovici L, Amit M, Weinberger A.
Department of Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Alopecia was observed in 40/74 (54%) patients with systemic lupus erythematosus (SLE). Patients with alopecia had a significantly higher rating for cutaneous manifestations, Raynaud's phenomenon and muscle tenderness, and most of these signs correlated with the magnitude of alopecia. There was no difference between patients with or without alopecia for arthritis, nephritis or central nervous system manifestations. Alopecia correlated with disease activity index but did not correlate with various specific measurements of disease exacerbation.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1941821&dopt=Abstract
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