References: Hair growth and hair loss
Hautarzt. 1991 Mar;42(3):168-72.
[Hyperprolactinemia and hypophyseal hypothyroidism as cofactors in hirsutism and androgen-induced alopecia in women]
[Article in German]
Schmidt JB, Lindmaier A, Spona J.
II. Universitats-Hautklinik, Wien.
A more comprehensive hormonal diagnosis than has previously been performed shows that androgen-dependent diseases of hair growth are due to more varied hormonal disturbances than elevated androgen serum levels alone. In 46 female patients with androgenic hair loss and 27 patients with hirsutism, the levels of the androgens testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulphate and 17-hydroxyprogesterone and of sex hormone-binding globulin, cortisol, oestradiol and the hypophyseal hormones follicle-stimulating hormone and luteinizing hormone were determined and compared with the hormone levels of 27 female patients without endocrine disorders. Of the androgens, only androstenedione showed a slightly significant elevation in hirsutism. Cortisol was elevated significantly in androgenic hair loss, and with a low degree of significance in hirsutism. In view of the complex hormonal interactions of thyroxin, prolactin and androgens and thyroid hormones the thyrotropin-releasing hormone (TRH)-stimulation test was performed in 38 female patients with androgenic hair loss and 27 with hirsutism, and the results were compared with those recorded in 45 female control persons. The test is based on feedback mechanisms between hypothalamic TRH and hypophyseal TSH and prolactin and peripheral thyroid hormones. Baseline concentrations of TSH prior to stimulation were significantly elevated in hirsutism, while in androgenic hair loss both baseline and stimulated TSH levels were significantly elevated; thus, hypothyroidism is a significant finding in both clinical pictures. In the case of prolactin, both baseline and stimulated levels were highly significantly elevated in hirsutism, while in androgenic hair loss the stimulated levels were significantly elevated.(ABSTRACT TRUNCATED AT 250 WORDS)
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Br J Dermatol. 1991 Aug;125(2):123-9.
Measurement of human hair growth by optical microscopy and image analysis.
Hayashi S, Miyamoto I, Takeda K.
Cosmetics Laboratory, Kanebo Ltd, Odawara, Japan.
We have developed a quantitative method for measuring hair growth using optical microscopy and image analysis, and have used this to investigate the rate of growth in subjects with and without alopecia. The hairs were cut from an area 7-8 mm in diameter and 24 h and 72 h later, images of the areas were obtained using an optical microscope and were recorded on a video disc. Measurements of the regrowing hairs, placed parallel to the scalp using a glass slide attached to the front of the microscope, were made using the image analyser. In subjects with little or no baldness there was a clear difference between fast-growing hairs and resting or slow-growing hairs. However, in subjects with alopecia there was no such difference and the growth rate of all the hairs showed a continuous distribution. Using this method other parameters such as the number of hairs per unit area and hair diameter as well as grouping of the hairs could be measured.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1911294&dopt=Abstract
Br J Dermatol. 1991 Aug;125(2):130-5.
Decreased sweat-gland number and function in patients with alopecia areata.
Elieff D, Sundby S, Kennedy W, Hordinsky M.
Department of Dermatology, University of Minnesota Hospitals, Minneapolis 55455.
In this study the number and function of sweat glands on the dorsum of the hand and foot were evaluated using a silastic imprint method. Twenty patients, 11 females and nine males with either alopecia areata, alopecia totalis, or alopecia universalis were included in the study. Patients showed a significant decrease in activated sweat-gland number and function compared to matched controls (P less than 0.001). There was no significant relationship between the degree of sweat-gland dysfunction and extent of hair loss, concurrent illnesses, or treatment. These findings suggest that eccrine sweat-gland function is compromised in patients with alopecia areata.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1911295&dopt=Abstract
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