References: Hair growth and hair loss
Am J Dermatopathol. 1991 Jun;13(3):248-56.
Cell degeneration in alopecia areata. An ultrastructural study.
Tobin DJ, Fenton DA, Kendall MD.
Unit of Cell Biology, U.M.D.S., London, England.
The morphology and prevalence of different forms of cell degeneration in hair follicles in acute alopecia areata were investigated. In addition to apoptosis and necrosis, a third morphological pattern of cell degeneration, dark-cell transformation, was evident. Fifteen patients with untreated acute alopecia areata and three normal adults without hair loss were studied. Electron microscopy revealed that although apoptosis of outer root sheath keratinocytes produces normal hair follicle involution (catagen), increased levels of apoptosis, necrosis, and dark-cell formation appear to be related to the pathology of alopecia areata. Although cell degeneration was generally restricted to keratinocytes of the lower follicle, melanocytes, Langerhans' and dermal papilla cells were also affected. Keratinocytic degeneration may affect layers of matrix cells in alopecia areata, unlike the apoptosis of scattered outer root sheath cells in normal catagen. The extent of cell death suggests a pathological rather than a physiological event in alopecia areata.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1867355&dopt=Abstract
Contact Dermatitis. 1991 Mar;24(3):183-6.
The loss of contact sensitization in man.
Valsecchi R, Rossi A, Bigardi A, Pigatto PD.
Department of Dermatology, Ospedali Riuniti di Bergamo, Italy.
Little is yet known about the duration of contact sensitivity, but frequent exposure of a target to allergen seems to reduce skin reactivity. The aim of this study was to study the persistence of a specific contact sensitivity in 66 patients with alopecia areata, previously sensitized to DNCB (31 patients) and SADBE (35 patients) between 1978-1985. Patch tests were performed with 0.020 ml of different concentrations of DNCB or SADBE in acetone (0.05%, 0.10%, 0.20%, 1%). The results were read in a standardized manner. Of 66 patients, 47 (71%) had positive reactions and 19 (29%) negative. 8 of the 19 negative patients had been treated with DNCB, 11 with SADBE. Approximately 1/3 of the patients previously sensitized had lost their original sensitivity, and this did not seem to be time-dependent. This phenomenon seemed to be clinically correlated because the majority of the patients were from the "low responders" group. We think that acquired unresponsiveness to topical antigen in man is a possible phenomenon, but that it occurs more rarely than in mice and guinea pigs.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1868701&dopt=Abstract
Chin Med J (Engl). 1991 Feb;104(2):164-7.
Soft tissue expansion in the treatment of scar alopecia in preschool children.
Wang SC, Chen FL, Li JY.
Department of Oral-Maxillofacial Surgery, Xinhua Hospital, Shanghai Second Medical University.
Indigenous rubber silicon gel soft tissue expanders were used to treat 5 preschool children with scar alopecia. The scar resection rate wa 100%; no severe complication happened. The average healing time was 25 days after the improvement of technical method. This method is simple, effective and the expansion duration is short.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1874016&dopt=Abstract
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