References: Hair growth and hair loss
J Adv Nurs. 1991 May;16(5):506-10.
Research in practice: an 'experiment' in researcher-practitioner collaboration.
Tierney AJ, Taylor J.
Nursing Research Unit, University of Edinburgh, Scotland.
There are signs that researchers and practitioners are seriously attempting to work more closely together to bring research and practice into closer alliance. This paper describes one such attempt in the form of an 'experiment' in collaboration between academic researchers and practising nurses in the undertaking of a practice-based research project. Positive benefits of collaborative research became evident and are highlighted in this paper. No attempt was made to evaluate the 'experiment' objectively and so this is a subjective account, aimed at encouraging other efforts towards closer collaboration between researchers and practitioners in nursing.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1856368&dopt=Abstract
J Invest Dermatol. 1999 Oct;113(4):687-90.
Atrichia with papular lesions resulting from a nonsense mutation within the human hairless gene.
Sprecher E, Lestringant GG, Szargel R, Bergman R, Labay V, Frossard PM, Friedman-Birnbaum R, Cohen N.
Department of Dermatology, Rambam Medical Center, Technion-Israel Institute of Technology, Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Atrichia with papular lesions is a rare autosomal recessive form of alopecia characterized by hair loss soon after birth and the development during childhood of a diffuse papular rash. We have previously shown that this disorder results from a deleterious mutation in the human hairless gene, a gene also involved in the pathogenesis of a related but clinically distinct form of congenital alopecia, termed alopecia universalis congenita. In this report, we describe a novel nonsense mutation in exon 4 of the human hairless gene in a consanguineous kindred affected with atrichia with papular lesions. This report provides additional evidence for phenotypic heterogeneity among inherited atrichias and for an association between the papular rash of atrichia with papular lesions and nonsense mutations in the human hairless gene.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10504459&dopt=Abstract
Vet Pathol. 1991 May;28(3):234-40.
Congenital anemia, dyskeratosis, and progressive alopecia in Polled Hereford calves.
Steffen DJ, Leipold HW, Gibb J, Smith JE.
Department of Pathology, College of Veterinary Medicine, Kansas State University, Manhattan.
A new syndrome of anemia, alopecia, and dyskeratosis was identified in Polled Hereford calves in this study. Cutaneous changes included hyperkeratosis and hair loss around the muzzle and ear margins, which progressed to a generalized alopecia and hyperkeratotic dermatitis. Histologically, orthokeratotic hyperkeratosis with dyskeratosis of epidermal and follicular keratinocytes was present. Alopecia was correlated with dyskeratosis of Huxley's layer and an increasing proportion of follicles in the telogen phase of the hair cycle. Dermatitis was characterized by a mild dermal mononuclear cell infiltrate and mild lymphocytic perivascular dermatitis. The anemia present at birth was nonprogressive and was classified as normochromic and normocytic to macrocytic. Reticulocytosis was absent, but bone marrow was markedly hyperplastic. Nuclear cytoplasmic asynchrony of the rubricyte and metarubricyte stages occurred in the bone marrow. Abnormal rubricyte nuclei and maturation arrest at the late rubricyte stage were common. Cytologic features of the erythroid series are similar to those of type I congenital dyserythropoietic anemia of human beings. Genealogic features suggest that this is a primary hereditary defect. The mode of inheritance, however, remains to be determined.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1858254&dopt=Abstract
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