References: Hair growth and hair loss
Cent Afr J Med. 1991 Oct;37(10):337-9.
Thyroid antibodies in alopecia totalis.
Pasaoglu H, Soyuer U, Astaal M.
Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri-Turkey.
Auto-antibodies to different thyroid cell components in serum of patients with thyroid disease have been estimated. Some types of antibodies were detected only in sporadic cases of nonthyroid auto-immune diseases. This study was performed on 24 patients who had alopecia totalis. Although they had normal serum free T3, T4 and TSH levels, five patients had significantly increased anti-microsomal antibody and one patient had both increased antithyroglobulin and antimicrosomal antibody levels. These results suggested that in alopecia totalis cases, it is reasonable to analyse thyroid antibodies because they can be taken as one part of the abnormal immune reactivity.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1813129&dopt=Abstract
Mayo Clin Proc. 1991 Apr;66(4):387-90.
Follicular mucinosis: histopathologic review of 33 cases.
Mehregan DA, Gibson LE, Muller SA.
Department of Dermatology, Mayo Clinic, Rochester 55905.
Among 33 patients with the histologic diagnosis of follicular mucinosis (alopecia mucinosa) made at our institution between 1982 and 1989, 9 had mycosis fungoides diagnosed concomitantly. Three other patients had lymphoproliferative disorders, and two had Kaposi's sarcoma. Analysis of biopsy features such as epidermal lymphocytic exocytosis, periappendageal infiltrate, and deposition of mucin revealed no predominant finding that distinguished a benign course from mycosis fungoides. A predominance of eosinophils in the infiltrate was suggestive of benign follicular mucinosis rather than mycosis fungoides. Gene rearrangement studies detected three clones in three patients with follicular mucinosis; two were in patients with mycosis fungoides, and one was in a patient with dermatitis. The outcome of these three patients is pending further follow-up. No histopathologic or clinical features distinguished these patients from the others.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1826537&dopt=Abstract
J Invest Dermatol. 1991 May;96(5):673-81.
Immunohistologic and ultrastructural comparison of the dermal papilla and hair follicle bulb from "active" and "normal" areas of alopecia areata.
Hull SM, Nutbrown M, Pepall L, Thornton MJ, Randall VA, Cunliffe WJ.
Department of Dermatology, General Infirmary, Leeds, England.
The "active" edges of patches of alopecia areata and normal areas from the same scalp (i.e., bearing normal terminal hair) from seven patients with alopecia areata were investigated immunohistologically. Similar areas from a further eight patients were examined using light and electronmicroscopy. "Active" and "normal" areas of alopecia areata scalps were immunohistologically similar and varied from normal controls in the number, distribution, and ratio for T4 and T8-positive cells. Similarly the ultrastructural changes seen in the "active" areas when compared to normal controls were also present in the "normal" areas of alopecia areata scalps. The most significant differences found between normal "control" follicles and both "active" and "normal" areas of alopecia areata scalps were the polymorphic nature of the dermal papilla cells and the loss of cellular organization within the dermal papillae taken from alopecia areata scalps. In addition, the junction between the dermal papilla and the bulb of the hair follicle, the dermo-epithelial junction of the hair follicle bulb, demonstrated critical changes in follicles taken from both "active" and "normal" areas of alopecia areata scalps. These results support the suggestion of a subclinical state of alopecia areata and indicate that further work on the etiology of alopecia areata should be directed towards the "normal" areas of alopecia areata scalps, in particular the cells of the dermal papilla and the dermo-epithelial junction of the hair follicle bulb.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1827135&dopt=Abstract
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