References: Hair growth and hair loss
Zhonghua Zheng Xing Wai Ke Za Zhi. 2000 Mar;16(2):105-7.
[Determination of scalp ER and AR of patients with male pattern baldness and the effects of hair transplantation on them]
[Article in Chinese]
Chen X, Long D, Wang S.
Department of Plastic Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060, PR China.
OBJECTIVE: To study the role of sex hormone receptor capacity of the scalp in male pattern baldness(MPB). METHODS: Estrogen receptor(ER) and androgen receptor(AR) assays were performed using fluorescent steroid hormone conjugate technique (FSHCT) in hairness and bald scalp in 8 patients with MPB. Changes of ER and AR capacity in recipient and donor sites of hair transplantation in MPB scalps were examined. RESULTS: The percentage of AR staining cells in the outer root sheath, sebaceous gland and bulb papilla of the lesional scalps was significantly higher than that of hairness scalps (P < 0.01). The percentage of ER positive cells in the outer root sheath of lesional scalps increased significantly (P < 0.01). CONCLUSION: Changes of contents of sex hormone receptors(SHR) in some sensitive area of the scalp induce MPB.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11593618&dopt=Abstract
Lab Anim. 1975 Jul;9(3):215-21.
An epizootic outbreak of ringworm in a guinea-pig colony caused by Trichophyton mentagrophytes.
Pombier EC, Kim JC.
The disease was characterized by loss of hair, initially occurring at the tip of the nose and spreading throughout the body. Lesions appeared as circular, scaley alopecia with occasional scarring. Although spread of the infection in the colony was random, the most severe infection occurred in an inbred line with light coat colour. The unusually high temperature and humidity, and the open type of outdoor management, appear to have contributed to the high incidence and severity of infection. Electron microscopic observation indicated that the organism multiplied in the keratin layer of the skin. The hyphae as well as chlamydospores were readily demonstrable by electron microscopy.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1160336&dopt=Abstract
Med J Aust. 1975 Jul 5;2(1):13-6.
Actinomycin D in the treatment of Paget's disease of bone.
Somerville PJ, Evans RA.
Fifteen patients with Paget's disease of bone were treated with actinomycin D for periods of up to 15 months. It was found that actinomycin D is effective in reducing the pain but not the neurological effects of Paget's disease. Careful adjustment of dose according to weight and initial response is necessary to prevent gastrointestinal side effects. If this is done, the risk of hepatic, renal, or haematological side effects is negligible.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1160708&dopt=Abstract
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