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For Women/menopause/PMS
Natural Wonder Woman, FeminiCare,... |
Date: Tue, 7 Jan 2003 23:49:06 -0800
Subject: [frontline-hepatitis-awareness] Progression of fibrosis in chronic hepatitis C
SourceURL:http://www.gastrohep.com/news/news.asp?id=1768
Progression of fibrosis in chronic hepatitis C
The best predictors of fibrosis progression in chronic hepatitis C are the
extent of serum aminotransferase elevations, degree of hepatocellular
necrosis, and inflammation on liver biopsy, find researchers from the
United States.
Fibrosis is a hallmark of hepatic cirrhosis. The worsening of fibrosis is
probably the best surrogate marker for progression of chronic liver disease.
In a study published in the January issue of Gastroenterology, researchers
evaluated 123 patients with chronic hepatitis C (CHC).
The research team used liver histology to assess the rate and predictors of
progression of fibrosis.
Patients in the study had undergone 2 liver biopsies 4 to 212 months apart
without intervening treatment.
The team graded the liver histology using the histology activity index.
39% of patients showed progression in fibrosis scores.
They also staged the fibrosis using a scoring system of 0 (no fibrosis) to
6 (cirrhosis).
The researchers found that of the 123 patients, 39% showed progression in
fibrosis scores, 37% showed no change, and 24% showed improvement.
Of those with worsening fibrosis, 75% had a 1-point increase and 25% a
2-point or greater increase in scores, and 9% showed progression to cirrhosis.
The team determined that the overall rate of progression was 0.12 fibrosis
units per year.
The rate of fibrosis progression was variable.
Progression was higher among older patients, those with higher serum
alanine and aspartate aminotransferase levels, and those with the most
extensive periportal necrosis on initial liver biopsy.
Dr Marc Ghany's team concluded, "The best predictors of fibrosis
progression in chronic hepatitis C are the extent of serum aminotransferase
elevations and the degree of hepatocellular necrosis and inflammation on
liver biopsy".
"These findings support the recommendation that patients with normal
aminotransferase levels and mild liver histology can safely defer treatment".
Gastroenterology 2003; 124(1): 97-104
07 January 2003
Date: Tue, 7 Jan 2003 08:36:30 -0500
Subject: [hepatitis-awareness] Asymptomatic Hepatitis C Virus Infection Widespread
DGReview
Asymptomatic Hepatitis C Virus Infection Widespread
A DGReview of :"Prevalence of Liver Disease in a Population of Asymptomatic
Persons with Hepatitis C Virus Infection"
Annals of Internal Medicine
01/06/2003
By Anne MacLennan
Hepatitis C virus (HCV) is histologically active and progressive in up to
40% of people who are asymptomatic for the infection, suggest researchers in
Italy.
Moreover, severity of liver disease correlates with abnormal ALT levels and
increases with age. These findings were reported by Dr Alfredo Alberti and
colleagues from the University of Padova, Padova.
Lack of clarity about prevalence of significant liver disease among those
who are asymptomatic for the HCV infection prompted this investigation of
4,820 apparently healthy people who underwent screening for cardiovascular
risk factors.
Objective of this cross-sectional study in north-eastern Italy was to
determine both prevalence and severity of HCV infection in this population.
In all cases, initial screening for anti-HCV by enzyme-linked immunosorbent
assay was followed by HCV RNA testing by polymerase chain reaction and
monitoring of alanine aminotransferase levels in those who were viremic.
(Ninety-two percent of viremics also had liver biopsies for assessment of
their METAVIR scores).
Overall, 116 people (2.4% [95% CI, 1.97% to 2.84%]) were positive for
anti-HCV. Eighty-five (1.76% [CI, 1.39% to 2.14%]) were also viremic.
The ALT level was persistently normal in 39 (46%) of viremic patients and
elevated in 46 (54%).
Investigators found significant hepatic histologic abnormalities in 19% (CI,
7.21% to 36.4%) of people with persistently normal ALT levels and in 61%
(CI, 45.4% to 74.9%) of viremics who had elevated ALT levels (P < 0.001).
Both prevalence of HCV infection and number of people with chronic liver
fibrosis increased with age (P = 0.003).
Ann Intern Med. 2002;137:961-964. "Prevalence of Liver Disease in a
Population of Asymptomatic Persons with Hepatitis C Virus Infection"
Date: Tue, 7 Jan 2003 07:12:07 -0500
Subject: [hepatitis-awareness] Interesting......Transfusion Alternative
Reported January 6, 2003
Transfusion Alternative
LOS ANGELES, Calif. (Ivanhoe Newswire) --
If you've ever had major surgery, you may have had a blood transfusion. But
the need for donor blood sometimes exceeds supply and donated blood still
carries a minor risk of infection. Now, an alternative to a traditional
blood transfusion has the medical world taking note.
Blood has always been the cornerstone of modern medicine. Often, trauma
victims and surgery patients need donor blood to stay alive.
Amateur artist Emily Gruszka needed blood when she came down with a serious
immune disorder called Evans Syndrome.
"My platelets were 7,000. Normal is 150,000 to 300,000 or so," Gruszka tells
Ivanhoe.
The problem was her body wouldn't accept a blood transfusion using donated
blood.
Gruszka says, "As the blood cells entered my system, my immune system would
recognize them as foreign substances like a disease."
Gruszka might have died, had her doctors not resorted to cutting-edge
medicine. They transfused her with a blood substitute made from the
hemoglobin of cows' blood, called Hemoglobin-Based Oxygen Carriers, or
HBOCs.
Anesthesiologist Jonathan Jahr, M.D., of UCLA Medical Center, tells Ivanhoe,
"It really is blood, but it's recombined in a brand new way into a new
packaging that can actually be room-temperature stable for up to three
years."
According to the American Red Cross, donated blood has a short shelf life --
approximately 42 days for red blood cells.
Dr. Jahr studied these HBOCs. Though their effectiveness didin't last long
once in the body, most patients in the study began making their own red
blood cells after four or five days.
"Sixty-percent of patients didn't require anybody else's red blood cells. So
we were able to avoid blood transfusions in 60 percent of patients who
otherwise absolutely would have received blood," says Dr. Jahr.
In Gruszka's case, the compound stabilized her long enough for doctors to
treat the underlying immune disorder. Today, she's fine, and she credits the
new blood substitute.
"It's about the only reason I'm alive," she says.
The new transfusion drugs can also be made of out-dated human blood. Best of
all, doctors say, HBOCs are accepted by all blood types. They could be
widely used in the United States within the next two years.
If you would like more information, please contact:
Biopure
http://www.biopure.com
Hemosol, Inc.
http://www.hemosol.com
Hepatitis and Health information and news resources
DreamPharm: herb mint
Aphrodisiac food for Valentine Day
Skin care cream e-mail scrap
Health information from e-mail scraps
Hepatitis information and various health issues from e-mail scraps
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