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Shengzhi Yu Biyun. 1982 Sep;2(3):3-7.
[Antifertility vaccine research--present status and prospects]

[Article in Chinese]

Wang YF.

PIP: There are a number of distinct advantages regarding immunological regulation of fertility, such as the indirect application of reversible antifertility vaccines, particularly if the immunocontraceptive used is highly specific. This approach toward contraception calls for the indirect inhibition of 1 or more of the reproductive precesses by treating the immune system, i.e., by regulating the relative concentrations of antigens and antibodies, the type of immunocomplex and the achieved effect may be artificially predetermined. In addition to the use of antigens which interfere with vital reproductive enzymes (i.e., cystine aminopeptidase), or the introduction of placenta-antigens which inhibit the production of key proteins (i.e., SP1 glycoprotein), other alternatives including anti-HCG and anti-LDH-X are also considered.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12312672&dopt=Abstract

Arch AIDS Res. 1987;1(2-3):198-205.
Immuno-andrology/IVF/AID/HIV.

Hafez ES, Zea HB, Arias E.

PIP: Several research projects are suggested related to artificial insemination by donor (AID), rectal insemination, autoimmunity in the male reproductive system and isoimmunity in the female tract and HIV transmission. The mixed antiglobulin reaction test is suggested as an early indicator of whether semen for donor insemination is free of HIV. Such semen should also be screened for hepatitis B. The immune responses to rectal insemination should be explored, as evidence from laboratory animals and homosexual men suggests that this practice may compromise the immune system. The possibility that the high titer of HIV in semen could adversely affect women using IUDs, via the exposed tail of the device, should be investigated. A protocol for insuring that semen for artificial insemination is free of HIV is presented. 21 other research experiments are suggested by title only, including 13 types of testing for studies of the immune response in malignancy.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12315311&dopt=Abstract

Jeune Afr. 1991 May 8-14;31(1584):34.
[Will AIDS overtake them?]

[Article in French]

Boukhari S.

PIP: UNICEF estimates that the streets are now the home of some 5 million African children aged 7-15 who are victims of rapid population growth and urbanization as well as the disintegration of traditional family structure. These children, deprived of a home and of all parental control, are potentially very vulnerable to the threat of AIDS. Prostitution, which is almost institutionalized in the most impoverished urban areas, represents for young girls the most immediate means of survival and occasionally even of helping their families. Male prostitution is highly tabu and marginal in sub-Saharan Africa, and is only slightly developed around the tourist hotels. Homeless children are somewhat protected against contamination through the blood by their lack of access to health care. Intravenous drugs are rare in Africa, and drug use is at most an indirect risk factor for AIDS to the extent that in increases the need for money and weakens the immune system. The frequency of sexually transmitted diseases, deplorable hygienic conditions, and poor general health of homeless children increase their risk of contracting the virus. Many homeless children do not even know of the existence of condoms and in any event condoms are usually inaccessible or too costly for them. Homeless children, like the general population, have false ideas about AIDS that discourage self-protective behaviors. In addition they are cut off from the activities of existing prevention programs. In a context of permanent daily insecurity, AIDS appears as just 1 more menace among others. According to an anthropologist working with the UNESCO program to help homeless children, the only way of making such children aware of the threat of AIDS in the large African cities will be to increase the number of prevention programs targeted at them. At the same time, the children need to be educated and taught an income-generating skill; in short, they need to be given a reason to believe in the future.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12316939&dopt=Abstract

J SOGC. 1993 Oct;15(8):921-4.
The intrauterine device today.

Rioux JE.

PIP: The intrauterine contraceptive device (IUD) is effective and reversible and has a high continuation rate. It can also be used within 7 days postcoitus. Developed separately by Richter, Grafenberg, and Ota between 1909 and 1934, the IUD gained popularity in the 1960s and 1970s with the introduction of the Margulies Spiral, the Lippes Loop, the Birnberg Bow, and the Dalkon Shield. The last proved dangerous, and the IUD became unpopular. The 4 IUDs which are available in Canada include the TCu-380S (GYNE T Slimline), the TCu-200, the NOVA-T, and the Progestasert. All are T shaped and medicated (copper or progesterone). The 1st and 3rd can be left in situ for 10 years; the 2nd, for 4 years; and the 4th, for 1 year. The NOVA-T has a copper wire with a silver core and is inserted with a unique pull-push technique. The Progestasert, which contains 38 mg of progesterone, releases 65 mcg of the hormone daily. The best candidate for IUD use is parous, but not pregnant, is in a stable monogamous relationship, and has a healthy reproductive tract and no history of ectopic pregnancy, sexually transmitted disease, pelvic inflammatory disease, undiagnosed genital bleeding, endometrial or cervical neoplasia, abnormal endometrial anatomy, compromised immune system, allergy to copper, or Wilson's Disease. The only infection related to the IUD is that associated with insertion. Such an infection is polymicrobial and involves the endogenous, cervicovaginal flora (primarily anaerobes). It is usually asymptomatic and contained by the immune system. 200 mg of Doxycycline can be given orally as a prophylactic 1 hour prior to insertion. A nonprescription, nonsteroidal, anti-inflammatory drug, also taken 1 hour before the procedure, will prevent pain and a vasovagal reaction. Paracervical anesthesia should be used. If the depth of the uterus is less than 6 cm or greater than 10 cm, another form of contraception should be used. Although little research is being done in Canada on new IUDs, the Levonorgestrel IUD from Europe and the CuFix-360 (Flexigard) offer promise. The former, which is T shaped, contains polydimethylsiloxane and levonorgestrel (52 mg, total; releases 20 mcg daily) and can be used for 7 years. The latter IUD is shapeless and consists of 6 copper sleeves strung on surgical nylon thread knotted at 1 end. The knot is inserted, using a needle, into the fundal myometrium. The truth and falsehood of several myths about IUDs are noted with supporting citations.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12318529&dopt=Abstract

Genre. 1994 Jun;(19):39-43, 97, 100.
Why do doctors hate this man?

Jones M.

PIP: Scientist Peter Duesberg's dismissal of human immunodeficiency virus (HIV) as the cause of acquired immunodeficiency syndrome (AIDS) and insistence that AIDS is a noninfectious disease has made him a focus of controversy in both the medical profession and homosexual community. Duesberg attributes the AIDS epidemic to heavy use of amphetamines and "poppers," which devastate the immune system and have been linked to the development of certain cancers such as Kaposi's sarcoma. He is concerned about the widespread, inappropriate use of AZT, which not only lacks proven efficacy but also destroys the immune system. Duesberg has termed AZT "AIDS by prescription," and considers it another cause rather than a cure of AIDS. There is no confirmation, he maintains, that the majority of AIDS patients have HIV. He further notes the radically different epidemiologic, immunologic, and clinical profile of African and American AIDS and suggests that these are two distinct disease process (the former caused by malnutrition, poor sanitation, and parasites and the latter by drugs) erroneously grouped under the same rubric. To perpetuate itself, the AIDS industry has developed a second line of defense in the argument that AIDS is multifactorial, with HIV plus a cofactor responsible for disease. Again, there is no empirical evidence to support this politically motivated theory. Of concern is the emphasis on promoting safe sex rather than urging an end of recreational drugs and AZT.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12318794&dopt=Abstract

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