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Afr Link. 1996 Apr;:25-6.
Male sexual health.

[No authors listed]

PIP: Sexually transmitted diseases (STDs) are diseases which can be contracted through vaginal, anal, and oral sexual intercourse. Common STDs are listed. AIDS is a collection of symptoms and diseases caused by HIV infection and the subsequent weakening of the human body's natural immune system. The stages of HIV infection are described. Prostate cancer is the growth of malignant cells in the prostate gland, the gland at the base of the urinary bladder in men which helps to create semen. This form of cancer generally affects men over age 50 years and may grow very slowly without causing symptoms or spreading to other parts of the body. The condition has no early symptoms and is most often discovered during a routine rectal examination. There are no specific preventive measures against prostate cancer, although an annual rectal examination after age 40 is the best way to detect the condition early. Male infertility remains a complex problem with many unknown aspects in need of intensive research. Male impotence refers to disorders of erection, lack of libido, or both conditions.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12292582&dopt=Abstract

Pac AIDS Alert Bull. 1997 Sep;(13):10-1.
What people need to know about new HIV treatments.

[No authors listed]

PIP: Despite the spate of recent news stories about revolutionary new and successful AIDS treatments and morning-after clinics against new HIV infection, safe sex remains the only sure way to avoid infection and stay healthy. There is still no cure for HIV infection, scientists have not been able to eliminate HIV from anyone who has been infected, and HIV treatments have difficult side effects, do not work for everyone, often have complicated dosing schedules, and are expensive. A growing range of options to treat HIV infection and AIDS is, however, available. For years, AZT was the only approved drug for people with HIV/AIDS. 11 anti-HIV drugs are now on the market, with at least 5 more drugs likely to become available over the next 2 years. Combining 3 or more of these two types of drugs, which interfere with HIV's ability to replicate, can dramatically reduce the viral load in many people; retrospective studies have shown that people with lower viral loads live longer. These drugs, if used quickly after exposure, may also be able to prevent infection. Post-exposure prophylaxis (PEP) refers to the use of anti-HIV drugs within hours of exposure to HIV in the attempt to avoid infection. A study of health care workers' use of PEP after on-the-job exposure found PEP to reduce the odds of infection by 79% for those who took AZT within hours of exposure by needle stick. A pilot study to be conducted in San Francisco will test the effectiveness of a 28-day PEP drug treatment regimen for people recently exposed to HIV. A new, and still imperfect, test capable of detecting HIV load in the blood as early as 4-7 days after exposure may be used to help identify candidates for PEP. The early use of available treatments may be able to keep the immune system healthy for a long time. Some scientists are also testing the theory that HIV may be able to be eradicated if detected early and treated aggressively for 3 or more years.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12293125&dopt=Abstract

Integration. 1998 Fall;(57):10-2.
Cure: myth or reality? Treatment.

Harrington M.

PIP: In this address to the 12th World AIDS Conference, Mark Harrington, an AIDS activist from the US presented his perspectives about the obstacles hindering efforts to cure AIDS. Harrington described the progress of his disease as revealed by a series of lymph node biopsies and reported that he successfully began highly active antiretroviral therapy (HAART) 11 years after he was infected. While he was grateful for his success, he expressed disgust that millions of people throughout the world do not have access to HAART. He asked whether those seeking a cure would be satisfied with a clinical or microbiological cure or would hold out for a complete genomic cure and noted that he was satisfied to live with a little provirus as long as his immune system can protect him from dying of AIDS. He then mentioned some of the additional approaches that researchers will take to try to increase the chances of a cure. Harrington expressed disagreement with researchers who urge infected individuals to go on therapy early, pointing out that periods of noncompliance could lead to drug resistance. He called for studies that would weigh the benefits and risks of early intervention and pointed out that a mistaken reliance on therapy has undermined prevention efforts. He also criticized cuts in funding for programs in developed countries and the lack of support offered by developed countries to AIDS programs in the developing countries hardest hit by the epidemic. He concluded by calling for a partnership of science and activism and for increased funding to combat HIV/AIDS.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12294615&dopt=Abstract

AIDS Wkly Plus. 1999 Jul 12-19;:3-4.
CDC warns of HIV "clusters" in low-prevalence areas.

Denoon DJ.

PIP: The US Centers for Disease Control and Prevention (CDC) recently reported an outbreak of HIV infection among a group of young women in rural Chautauqua county, New York, who apparently contracted HIV from a single, highly infectious man. Although the index case refused to donate blood for analysis, 13 of the 47 women who had sex with the man became infected. The 10 primary contacts who provided blood samples for analysis were infected with highly similar viruses. The 13 women who apparently acquired HIV from the index case had sex with 84 secondary contacts. The resulting AIDS scare led to the counseling and HIV testing of approximately 1400 people in the county, which led to the identification of other HIV-infected individuals unrelated to the index case. The 31% rate of infection transmitted by the index case suggests that HIV can be spread rapidly by only a few individuals. It used to be thought that a person is most likely to transmit HIV either during acute infection, before the immune system has fully responded to the virus, or late in infection when the immune system has been destroyed. Neither sexually transmitted diseases nor IV drug use was associated with HIV transmission in this cluster of cases.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12295183&dopt=Abstract

AIDS Wkly Plus. 1999 Jul 12-19;:5.
Interleukin treatment developed for HIV positive patients.

[No authors listed]

PIP: A treatment of interleukin II (IL-2) is being developed as an immune stimulant for HIV-positive individuals who have responded to medication, but have not had their immune system recover. While new antiviral drugs are effective in inhibiting HIV, they have not been shown to restore a patient's damaged immune system. IL-2 therapy will be administered to promote the return of normal helper T cells and boost the number of cytotoxic T cells which can then destroy HIV-infected cells. Pioneered by researchers at Weill Medical College of Cornell University, New York, the low-dose, nontoxic regimen is being investigated in clinical trials. IL-2 has been used as an immune stimulant for cancer patients for more than 10 years. More recently, HIV-positive individuals have been treated with high doses of IL-2, but experienced severe side effects. IL-2 could therefore only be given for a few days every 2 months. This new regimen is different because it involves the daily low-dose administration of IL-2. Since it appears to be completely nontoxic, patients can be treated without interrupting their daily lives.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12295184&dopt=Abstract

The average human scalp is covered by approximatey 100,000 hair follicles. Each hair undergoes Loss of hair itself does not pose critical health problems because biological role of human hair is relatively marginal. Hair on our scalp protects the head from mechanical shock, heat loss, and exposure to UV-light. The eyelashes and eyebrowes protect the eyes, and hair in the ear canal or the nasal passages help filter out particles and pathogens, thus protecting our internal organs. However, hair does play important social role: it is one of the major determinants of our appearance and identity in daily life. Fullness of hair also implicates or manifests physical integrity and youthfulness of the person. Losing hair could have more than just emotional impacts on individuals. The hair is a unique organ that goes through a characteristic cycle consisting of an immature phase, a growing phase called anagen, a transitional phase between the growing phase and the resting phase called catagen, and finally a resting phase called telogen in which the hair stops growing, waiting to fall out. 85-90% of hairs on our body are in anagen phase or growing phase, which lasts anywhere from two to five years. This phase is followed by a short regression phase, or catagen, which lasts 2-3 weeks. Approximately 1% of hair follicles are in catagen. Approximately 10-15% of hair follicles are in the resting phase, the telogen, which lasts about 3-5 months. Hair follicles typically goes through 10-20 asynchronous cycles during the lifetime. Persistent loss of more than 150 hairs would consist a state of hair loss, or alopecia, albeit it could be temporary.

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