DreamPharm Products:
Vaccine. 2002 Sep 10;20(27-28):3304-9.
Protection against tetanus toxin after intragastric administration of two recombinant lactic acid bacteria: impact of strain viability and in vivo persistence.
Grangette C, Muller-Alouf H, Geoffroy M, Goudercourt D, Turneer M, Mercenier A.
Departement de Microbiologie des Ecosytemes, Institut Pasteur de Lille, 59019 Lille Cedex, France. corinne.grangettbl.fr
Non-pathogenic lactic acid bacteria (LAB) are attractive as live carriers to deliver protective antigens to the mucosal immune system. Both persisting and non-persisting strains of lactic acid bacteria have been evaluated and seem to work equally well by the systemic and nasal routes of administration. However, it is not known if persistence and viability of the strain play a critical role when immunizing by the oral route. To address this question, recombinant LAB strains, able to persist (Lactobacillus plantarum NCIMB8826/pMEC127) or not (Lactococcus lactis MG1363/pMEC46) in the gastro-intestinal tract of mice and producing equivalent amounts of the tetanus toxin fragment C (TTFC) were compared to each other. A very strong ELISA TTFC-specific and protective humoral response was elicited by either live or UV-inactivated recombinant Lb. plantarum strains. In a similar protocol, recombinant Lc. lactis seemed to be somewhat less efficient than the former host. It is thus tempting to propose that the difference in the capacity of the bacterial vector to persist in the gastro-intestinal tract impacts on its immunogenicity and on the level of protection it may induce. Protection was slightly superior after administration of live strains.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12213400&dopt=Abstract
Exp Gerontol. 2002 Aug-Sep;37(8-9):1077-88.
Thymic sensitivity to hypoxic condition in young and old rats. Age-dependent expression of NF-kappaB.
Trubiani O, Di Giulio C, Tripodi D, Bianchi G, Paganelli R, Di Primio R.
Department of Odontostomatology, University of Chieti-Pescara, Via dei Vestini 32, 66100 Chieti, Italy.
Oxygen keeps the entire enzymatic machinery in its physiological state. Senescence is associated with damage caused by oxidative stress, affecting also the immune system. In this study the effect of chronic hypoxia for 12 days on young and elderly rat thymus was investigated. The significant changes in cell thymic organization in young and old-aged rat thymus, with redistribution of thymic cells and stroma, were even more marked after prolonged hypoxia. These were further associated to down-regulation of NF-kappaB expression in young rats but up-regulation in old rats. Reorganization of thymic compartments together with disregulated expression of transcription factors, mainly expressed by 'common' thymocytes, may be related to an altered function under hypoxic conditions, inducing opposite responses in young and aged thymuses, probably related to different states of basal oxidative stress.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12213558&dopt=Abstract
J Pediatr Hematol Oncol. 2002 Dec;24(9):772-6.
Autoimmune thyroiditis after bone marrow transplantation in a boy with Wiskott-Aldrich syndrome.
Olivares JL, Ramos FJ, Olive T, Fillat C, Bueno M.
Departamento de Pediatria, Facultad de Medicina, Universidad de Zaragoza c/Domingo Miral s/n 50009 Zaragoza, Spain. olivareosta.unizar.es
We report a boy with Wiskott-Aldrich syndrome (WAS) who developed autoimmune thyroiditis 19 months after allogenic bone marrow transplantation (BMT). Possible causes of his autoimmune illness were 1) transference of autoimmune cells from the donor, which was ruled out because of the absence of autoimmune illness in his healthy HLA-identical brother (donor); 2) persistent mixed chimerism after BMT ruled out by post-BMT molecular analysis of the proband's peripheral lymphocytes; and 3) patient's predisposition to autoimmune disease secondary to an dysregulated immune system because of WAS and his HLA haplotype. This case brings previously unreported findings to the spectrum of WAS.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12468924&dopt=Abstract
Biochem Pharmacol. 2002 Sep;64(5-6):781-8.
The c-Jun N-terminal kinases in cerebral microglia: immunological functions in the brain.
Hidding U, Mielke K, Waetzig V, Brecht S, Hanisch U, Behrens A, Wagner E, Herdegen T.
Institute of Pharmacology, Hospitalstrasse 4, 24105 Kiel, Germany.
The c-Jun N-terminal kinases (JNKs) exert a pleiotrophy of physiological and pathological actions. This is also true for the immune system. Disruption of the JNK locus results in substantial functional deficits of peripheral T-cells. In contrast to circulating immune cells and the role of p38, the presence and function of JNKs in the immune cells of the brain remain to be defined. Here, we report on the expression and activation of JNKs in cultivated microglia from neonatal rats and from mice with targeted disruption of the JNK locus and the N-terminal mutation of c-Jun (c-JunAA), respectively. JNK1, 2 and 3 mRNA and proteins were all expressed in microglia. Following stimulation with LPS (100 ng/mL), a classical activator of microglia, JNKs were rapidly activated and this activation returns to basal levels within 4 hr. Following LPS and other stimuli such as thrombin (10-50 unit/mL), the activation of JNKs went along with the N-terminal phosphorylation of c-Jun which persisted for at least 8 hr. Indirect inhibition of JNK by CEP-11004 (0.5-2 microM), an inhibitor of mixed-lineage kinases (MLK), reduced the LPS-induced phosphorylation of both, JNK and c-Jun, by around 50%, and attentuated the LPS-induced the alterations in microglial morphology. Finally, JNKs are involved in the control of cytokine release since both, incubation with CEP-11004 and disruption of the JNK1 locus enhanced the release of TNFalpha, IL-6 and IL-12. Our findings provide insight in so far unknown functions of JNKs in cerebral immune cells. These observations are also important for the wide spread efforts to develop JNK-inhibitors as neuroprotective drugs which, however, might trigger pro-inflammatory processes.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12213570&dopt=Abstract
Nature. 2002 Sep 5;419(6902):43-8. Epub 2002 Jul 31.
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.
Di Noia J, Neuberger MS.
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region (IgV) genes are diversified after gene rearrangement by hypermutation. In the DNA deamination model, we have proposed that deamination of dC residues to dU by activation-induced deaminase (AID) triggers this diversification. In hypermutating chicken DT40 B cells, most IgV mutations are dC --> dG/dA or dG --> dC/dT transversions, which are proposed to result from replication over sites of base loss produced by the excision activity of uracil-DNA glycosylase. Blocking the activity of uracil-DNA glycosylase should instead lead to replication over the dU lesion, resulting in dC --> dT (and dG --> dA) transitions. Here we show that expression in DT40 cells of a bacteriophage-encoded protein that inhibits uracil-DNA glycosylase shifts the pattern of IgV gene mutations from transversion dominance to transition dominance. This is good evidence that antibody diversification involves dC --> dU deamination within the immunoglobulin locus itself.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12214226&dopt=Abstract
While the hair loss and resulting baldness in general have not been proven to be related to underlying health problems, there are certain correlations between hair loss and health problems. For instance, premature hair loss could suggest premature aging or nutritional and hormonal imbalances, stressful life, use of drugs that cause hair loss as a side effect, skin disease, or heart disease. The balding appearance could also impart a subdued impression of integrity in bodily health and youthfulness. Fortunately, in many cases, hair loss is reversible by change in lifestyle and/or nutritional supplementation. Herbal hair growth formula and other nutritional supplements have been shown to be effective in warding off hair loss and resuming hair growth. Certain prescription drugs such as Propecia may also reverse hair loss by blocking the formation of DHT, a hormonal byproduct produced inceasingly as a person age.
DHEA has been suggested to provide numerous potential benefits. DHEA (or dehydroepiandrosterone) is converted into androgens (male hormones)
or estrogens (female hormones) in the cells.
Our bodies produce decreasing amount of DHEA as we get older.
various health benefits: To deter aging,
improve sexual function/erectile dysfunction, treat cognitive decline, enhance athletic performance,
facilitate weight loss, improve strength, prevent osteoporosis, enhance immunomodulation for rheumatic conditions,
and treat depression.
Rx Medications Online||
Constipation relief, laxative, colon cleansing ||
Best Realtor in Glendale, California: Residential Home and Commercial Property ||
Related Web pages ||
Herbs and Pharmaceuticals Online ||