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Alopecia, hair loss abstracts ||

Comp Med. 2003 Apr;53(2):213-7.
Alopecia attributed to neoplastic ovarian tissue in two ferrets.

Patterson MM, Rogers AB, Schrenzel MD, Marini RP, Fox JG.

Division of Comparative Medicine, Massachuetts Institute of Technology, Cambridge 02139, USA.

Ferrets with adrenal gland dysfunction have alopecia as their most common clinical sign of disease. Two cases of alopecia in neutered female ferrets are reported that were associated instead with neoplastic tissue found at the site of an ovarian pedicle. Androstenedione and 17-hydroxyprogesterone, but not estradiol, concentrations were high in both ferrets. Following surgical resection of the abnormal tissue in one ferret, the high hormone values decreased quickly and hair regrowth ensued. In both cases, histologic examination revealed features consistent with classical sex cord-stromal (gonadostromal) tumors: prominent spindle cells, along with polyhedral epithelial cells and cells with vacuolated cytoplasm. Although similiar cell types have been described in the adrenal glands of ferrets with adrenal-associated endocrinopathy, an ovarian origin for the current neoplasms is considered likely on the basis of their anatomic location; accessory adrenal tissue has only been described close to an adrenal gland or in the cranial perirenal fat of ferrets. Immunohistochemical analysis, using an antibody against Mullerian-inhibiting substance, failed to prove definitively the source of the steroidogenic cells.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12784857&dopt=Abstract [PubMed - in process]

Int J Dermatol. 2003 Jun;42(6):434-7.
Alopecia areata: psychiatric comorbidity and adjustment to illness.

Ruiz-Doblado S, Carrizosa A, Garcia-Hernandez MJ.

Consultation-Liaison Psychiatric Unit, Osuna Hospital, and Department of Dermatology, School of Medicine, University of Seville, Seville, Spain. sergioruiica.es

BACKGROUND: Decades ago, alopecia areata (AA) was regarded as a well-known example of psychosomatic disease. The poor development of measurement methods and criteria for the classification of psychiatric disorders at that time was probably partly to blame for the lack of methodologic validity of some studies. METHODS: We studied a random sample of 32 patients with AA (patchy form). Sociodemographic, dermatologic, and psychiatric variables were collected. Psychiatric examination was carried out by standardized interviews: Schedules for Clinical Assessment in Neuropsychiatry (SCAN), International Personality Disorders Examination (IPDE), and Psychological Adjustment to Illness Scale (PAIS), using the Research Diagnostic Criteria of the International Classification of Diseases, 10th edition, to assess the diagnosis. A descriptive and association study was performed, correlating the patient's adjustment and adaptation to the illness to various factors (linear regression techniques and analysis of variance). RESULTS: Sixty-six per cent of patients presented with psychiatric comorbidity, mainly adjustment disorders (F.43.2), generalized anxiety disorders (F.41.1), and depressive episodes (F.32). Overall adaptation to the illness, however, was satisfactory, showing few repercussions in family or social life, work, or sexual adjustment. Poor adjustment was associated with a dependent personality (Pearson's r = 0.66), antisocial personality (r = 0.39), generalized anxiety (P = 0.003), and depression (P = 0.02). CONCLUSIONS: There is a high psychiatric comorbidity in AA (anxiety and mood disorders), requiring systematic psychiatric evaluations of these patients. A satisfactory overall adaptation to mild/moderate forms of the disease is the norm, but adaptation and comorbidity in severe forms (totalis, universalis) are unknown. A dermatology/liaison psychiatry setting could improve the management of AA.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12786868&dopt=Abstract [PubMed - in process]

Eur J Cancer Care (Engl). 2003 Jun;12(2):154-61.
The effectiveness of scalp cooling in preventing alopecia for patients receiving epirubicin and docetaxel.

Macduff C, Mackenzie T, Hutcheon A, Melville L, Archibald H.

Centre for Nurse Practice Research and Development, The Robert Gordon University, Aberdeen, UK. c.macdufgu.ac.uk

The aim of this study was to establish the effectiveness of scalp cooling in preventing alopecia for patients with breast cancer who received the trial combination chemotherapy of Epirubicin and Docetaxel. Doubt remains about the general effectiveness of scalp cooling in preventing hair loss for patients receiving chemotherapy. There is very little information available about its specific effectiveness with combinations of Taxanes and Anthracycline drugs. Of the 40 patients who received this drug combination, 10 were included in a pilot study whereas the remaining 30 constituted the main study sample. A randomized controlled study was undertaken whereby the intervention group received scalp cooling via gel cool caps and the control group received no specific preventative intervention. Nurses assessed participants' hair loss using a modified version of the WHO scale at seven time points and also recorded hair loss photographically. Two independent experts rated the photographs using the same scale. Patients self-reported in relation to overall hair loss, hair condition, levels of emotional upset, negativity about appearance, hair re-growth and wig use. Significantly greater hair loss was apparent in the control group during most of the treatment period. However, the level of protection afforded by the cool caps was relatively poor with this chemotherapy combination. The marginal benefits of scalp cooling in this context must be clearly explained to patients.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12787013&dopt=Abstract [PubMed - in process]

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