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J Am Acad Dermatol. 2002 Nov;47(5):733-9.
Hair loss in women with hyperandrogenism: four cases responding to finasteride.

Shum KW, Cullen DR, Messenger AG.

Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK.

Oral finasteride, a type II 5 alpha-reductase inhibitor, has been shown to increase hair growth and slow progression of thinning in men with androgenetic or male pattern balding (Hamiliton type) but has no affect on hair growth in postmenopausal women with female pattern hair loss (Ludwig type). We describe 4 cases of hair loss with characteristics of both male and female patterns in women with hyperandrogenism in which finasteride has improved or stabilized the alopecia. Improved hair growth was seen after 6 months, 1 year, 2 years, and 2.5 years, respectively. The finding that finasteride treatment improves pattern hair loss in women with hyperandrogenism but does not affect those postmenopausal women with female pattern hair loss without hyperandrogenism supports the concept that not all types of female hair loss have the same pathophysiology.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12399766&dopt=Abstract

Gan To Kagaku Ryoho. 2002 Oct;29(10):1759-63.
[Pharmacologic study of intraperitoneal docetaxel in gastric cancer patients with peritoneal dissemination]

[Article in Japanese]

Fushida S, Nao F, Kinami S, Ninomiya I, Fujimura T, Nishimura G, Ohta T, Yokogawa K, Miyamoto K, Miwa K.

Division of Cancer Medicine, Graduate School of Medicine, Kanazawa University.

This study was designed to evaluate the pharmacokinetics and toxicity of docetaxel administered via an intraperitoneal (i.p.) route for patients with gastric cancer. Eleven patients with peritoneal dissemination were entered into this trial. Patients were treated with 45 mg/m2 of i.p. docetaxel administration in 1 l of saline. Peak peritoneal concentration was 40.0 +/- 14.5 micrograms/ml and peritoneal concentration at 24 hours after drug administration was 4.3 +/- 3.9 micrograms/ml. The median pharmacokinetic advantage (AUC peritoneal/AUC plasma) was 515 (range 22-1, 770). Grade 2 and 3 toxicities included 5 episodes of diarrhea; 3 of abdominal pain; 3 of ascites; 2 of alopecia; and 1 of neutropenia. We conclude that intraperitoneal docetaxel administration is well tolerated and provides a peritoneal pharmacokinetic advantage for the treatment of peritoneal dissemination.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12402426&dopt=Abstract

Gan To Kagaku Ryoho. 2002 Oct;29(10):1841-4.
[A case of postoperative liver metastasis from gastric cancer which responded well to weekly chemotherapy with paclitaxel]

[Article in Japanese]

Yamamoto D, Hamada Y, Yamamoto C, Inoue K, Yamamoto M.

Dept. of Surgery, Seiko Hospital.

We report a case of postoperative liver metastasis from gastric cancer showing a remarkable response to weekly administration of paclitaxel (TXL). The patient was a 50-year-old woman who underwent total gastrectomy. One month later, liver metastasis and a small amount of ascites were detected by CT scan. Therefore, the patient was administered weekly TXL. TXL (80 mg/m2) was infused over 1 hour after short premedication on an outpatient basis. Administration was continued for 3 weeks followed by 1 week rest. Liver metastasis and ascites disappeared 3 months after administration. The toxic events were leukopenia (grade 1) and alopecia (grade 1). No major adverse effects were observed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12402440&dopt=Abstract

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