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Vet Pathol. 2002 May;39(3):390-2.
A variant of pulmonary alveolar microlithiasis in nackt mice.

Starost MF, Benavides F, Conti CJ.

University of Texas M.D. Anderson Cancer Center, Department of Veterinary Sciences, Bastrop 78602, USA. mstarosdanderson.org

Four adult mutant nackt mice, which demonstrate alopecia and CD4+ T-cell deficiency, and two outbred SENCAR mice (sentinels) were presented for routine health surveillance. Lesions were not observed at necropsy. Microscopically, all four nackt mice demonstrated multiple concretions that were 30-100 microm in diameter, irregularly rounded to oval, nonbirefringent, and amphophilic to basophilic. Many of the concretions appeared attached to or within the alveolar walls of all lung lobes. Approximately half of the concretions had irregular fracture lines. All concretions were periodic acid-Schiff positive, and Von Kassa staining revealed diffuse calcification. None of the concretions were associated with inflammatory cell infiltrates, and metaplastic ossification was not evident. A diagnosis of pulmonary alveolar microlithiasis, a rare disease in both humans and animals, was made based on the size and location of the concretions and the lack of an inflammatory response. This is the first report of a laboratory mouse demonstrating pulmonary alveolar microlithiasis.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12014504&dopt=Abstract



Med Hypotheses. 2002 Apr;58(4):261-3.
Hormone-induced aberrations in electromagnetic adhesion signaling as a developmental factor of androgenetic alopecia.

Matilainen VA, Keinanen-Kiukaanniemi SM.

Department of Public Health Science and General Practice, University of Oulu, Finland.

In androgenetic alopecia, overactivation of the androgen hormone cascade in genetically predisposed persons leads to miniaturization of the dermal papilla of the hair follicle and to reduction in the number of papilla cells in the scalp, but the mechanisms explaining this miniaturization have remained unclear. According to our hypothesis, the increase of dihydrotestosterone (DHT) production in the overactive androgen state inhibits cell mitosis in the dermal papilla and contributes to the induction of programmed cell death (apoptosis). Normally, DNA molecules have a negative charge, which doubles in every cell mitosis. In the catagen and telogen phases, the sulphur-rich hair moves upwards, dehydrates and develops an increasing positive charge. In a normal hair-growth cycle, the epithelial column shortens and the secondary germ is formed and it invaginates the dermal papilla by electromagnetic attraction. In the mitotic inhibition state induced by DHT, the negative charge decreases, leading to a weakening of the electromagnetic adhesion forces and weaker electrical attraction between the undifferentiated germ cells and the dermal papilla. Insulin resistance has an additional pathogenic role in the excessive miniaturization of the hair follicle. The vasoactive substances associated with endothelial dysfunction in insulin resistance induce microcirculatory disturbance, perifollicular vasoconstriction and stimulation of smooth muscle cell proliferation in the vascular wall. This leads to microvascular insufficiency and local tissue hypoxia and progressive miniaturization of hair follicles. 2002 Elsevier Science Ltd. All rights reserved.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12027516&dopt=Abstract



Ter Arkh. 2002;74(4):39-42.
[Systemic lupus erythematosus and infectious endocarditis: similarities and differences]

[Article in Russian]

Tamarchenko IP, Komarov VT.

AIM: To compare clinical laboratory data in systemic lupus erythematosus (SLE) and infectious endocarditis (IE) for analysis of similar and different features. MATERIAL AND METHODS: Clinical and laboratory findings were compared for 72 IE and 71 SLE patients examined for a decade. RESULTS: SLE and IE have the following common features: fever, pleurisy, pericarditis, hemorrhagic vasculitis, articular syndrome, renal disorders, anemia, rheumatoid factor (RF), cryoproteins (CP), elevated ESR, concentrations of circulating immune complexes (CIC), IgM. Characteristic of SLE were skin erythema, alopecia, Raynaud's syndrome, cerebrovasculitis, lymphadenopathy, pneumonitis, frequent articular lesions, leucopenia, high IgG levels, CP and antibodies to DNA. IE was characterized by thromboembolic complications, splenomegaly, pneumonia, high CIC and medium mass molecules concentration, high incidence rate of RF, positive hemoculture. CONCLUSION: In spite of known differences between IE and SLE, in some cases differential diagnosis is not easy to make. This leads to late etiopathogenetic therapy.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12043236&dopt=Abstract








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