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J Intellect Disabil Res. 2000 Oct;44 ( Pt 5):621-3.
Celiac disease and alopecia areata in a child with Down's syndrome.

Storm W.

Kinderklinik St Vincenz Krankenhaus, Paderborn, Germany.

According to recent reports in the literature, there seems to be an association between alopecia areata and celiac disease. The present author describes a 9-year-old girl with Down's syndrome, and alopecia areata, and documented celiac disease, who displayed a normal growth of hair after a gluten-free diet. Given the high prevalence of these two diseases in patients with Down's syndrome, the present author recommends both serological screening for celiac disease in every individual with Down's syndrome, and in particular, the inclusion of such screening in any diagnostic work-up for alopecia areata.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11079358&dopt=Abstract

Panminerva Med. 2002 Dec;44(4):349-52.
Prevalence and clinical features of skin diseases in chronic HCV infection. A prospective study in 96 patients.

Paoletti V, Mammarella A, Basili S, Paradiso M, Di Franco M, De Matteis A, Musca A.

Department of Medical Therapy, University La Sapienza of Rome, Rome, Italy. vincenzo.paolettniroma1.it

BACKGROUND: Between extra-hepatic manifestations of hepatitis C virus (HCV) infection particular interest is focused on some dermatological diseases such as: leukocytoclastic vasculitis, oral lichen planus, pruritus-urticaria, psoriasis, etc. The aim of this study was to determine the prevalence of some dermatoses in our population of patients with HCV infection and describe the more characteristics clinical pictures. METHODS: Ninety-six patients (36 men and 60 women) aged from 35 to 74 years with HCV documented by 3rd generation ELISA and RIBA tests were prospectively examined for 3 years to determine the prevalence of some skin disorders, reported as associated with HCV infection. All patients were also studied for presence and quantification of HCV-RNA by polymerase chain reaction and genotyping when possible. Eighty-one underwent a liver biopsy. Routine laboratory tests and some immunological investigations (ANA, AMA, SMA, LKM, ANCA, ICC, crioglobulins) were performed using standard procedures and indirect immunofluorescence, nephelometric, RIA methods. RESULTS: Twelve of 96 patients (12.5%) presented skin disorders in progress of chronic virus C hepatitis: 5 cases of leukocytoclastic vasculitis (LCV) by mixed cryoglobulinemia, 1 case of pruritus, 2 cases of oral lichen planus (OLP), 2 cases of alopecia areata, 1 case of urticaria, 1 case of psoriasis. CONCLUSIONS: Our findings show a calculated prevalence of clinical dermatoses in HCV infected patients around 12.5%. These findings confirm however the importance of liver examination in presence of skin diseases not related to other pathogenetic mechanisms.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12434117&dopt=Abstract

Med Pregl. 2002 Jul-Aug;55(7-8):325-8.
[Psoriasis and autoimmune skin disorders]

[Article in Serbo-Croatian (Roman)]

Poljacki M, Begenesic M, Duran V, Matovic L, Matic M, Jovanovic M, Stojanovic S, Ros T.

Klinika za kozno-venericne bolesti, 21000 Novi Sad, Hajduk Veljkova 1-3. cojanunet.yu

INTRODUCTION: Presuming that psoriasis is an autoimmune skin disease, the aim of this study was to establish its association with other autoimmune skin diseases. The material was obtained at the Dermatovenereological Clinic--Clinical Center Novi Sad. MATERIAL AND METHODS: This 10-year retrospective study (1990-1999) included 1743 psoriasis patients. The control group consisted of 7492 nonpsoriatic dermatological patients. RESULTS: Association of psoriasis with other dermatological diseases of autoimmune nature has been established in 13 (0.74%) patients. The most frequent association was with lichen ruber planus in five patients, with alopecia areata and vitiligo in three patients, and in one with bullous pemphigoid and herpetiform dermatitis. Using Fisher's test no significant association was established. DISCUSSION AND CONCLUSION: According to literature data association of psoriasis with other autoimmune diseases is well known, but rare, which is in accordance with our results. The question arises whether this association is the matter of poor coexistence or the matter of genetic mutations. However, once established, these associations can further highlight the autoimmune nature of psoriasis. The research of autoimmunity would lead us to epithelial cells in thymus, and their badly learnt cognitive function about what is own, and what is not.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12434680&dopt=Abstract

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