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Alopecia, hair loss abstracts ||

J Eur Acad Dermatol Venereol. 2003 Mar;17(2):223-6.
Tufted hair folliculitis associated with pemphigus vulgaris.

Jappe U, Schroder K, Zillikens D, Petzoldt D.

Department of Dermatology, University of Heidelberg, Germany. Uta_Japped.uni-heidelberg.de

Tufted hair folliculitis (THF) is a rare disease which is characterized by the emergence of multiple hairs from widely dilated follicular orifices surrounded by an inflammatory infiltrate resulting in scarring alopecia. The pathogenesis is not yet fully understood. Although colonization with Staphylococcus aureus could not always be detected and systemic treatment with antibiotics alone is not sufficient, this microorganism is considered to play an important role. Around 30 patients with THF have been reported since the first publication. We present a patient with pemphigus vulgaris who developed THF. To our knowledge, this is the fourth case with an association of these two entities. Amongst other causing mechanisms, the autoimmune reaction may play an important role for the development of THF.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12705759&dopt=Abstract

Hautarzt. 2000 Oct;51(10):729-32.
[Interrelations between physician, hairdresser and mass media in management of hair loss]

[Article in German]

Trueb RM; Schweizerische Arbeitsgruppe fur Trichologie.

Dermatologische Klinik, Gloriastrasse 31, 8091 Universitatsspital Zurich, Schweiz. ramitrerm.unizh.ch

Hair problems are attacked at the levels of information supply, trichological competence and evidence based medical treatment. The alopecias represent a major health care challenge, and the psychological significance of hair loss has only recently found appreciation in the medical community. They may pose a vexing problem for non-specialized physicians, who tend to trivialize such complaints, although the patient's perception of abnormality determines whether or not advice is sought. Perception of a hair problem is subject to sociocultural standards; films and advertisements help determine the threshold for "normality" and what is "healthy" and "beautiful", and the media provide an abundance of undiscriminating information with respect to hair care. Patients with hair problems frequently consult the hairdresser prior to the medical specialist. Thus additional areas of competence should be incorporated into the hairdresser's training qualifications. Besides manual, creative and psychological aptitudes, "trichological competence" relating to the recognition of most important hair disorders, recognition of personal limitations and cooperation with the medical specialist are required. To optimize the interaction between the physician, hairdressers and the media, more effective communication and public activities from the medical profession are desirable, with success depending on full identification of the set goals, qualification and adherence to the standards determined by the medical speciality.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11153357&dopt=Abstract

Blood. 2001 Feb 15;97(4):880-5.
Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation.

Pignata C, Gaetaniello L, Masci AM, Frank J, Christiano A, Matrecano E, Racioppi L.

Department of Pediatrics and Cellular and Molecular Biology and Pathology, "Federico II" University, Naples, Italy. pignatnina.it

Human Nude/SCID (severe combined immunodeficiency) is the first severe combined immunodeficiency caused by mutation of the winged-helix-nude (WHN) gene, which is expressed in the thymus but not in the hematopoietic lineage. The disease is characterized by a T-cell defect, congenital alopecia, and nail dystrophy. A Nude/SCID patient who underwent bone marrow transplantation from the human leukocyte antigen-identical heterozygote brother was studied to investigate, in this unique model, the role of the thymus in immunologic reconstitution. Despite an increase in CD3(+), CD4(+), and CD8(+) cells, CD4(+) CD45 RA naive lymphocytes were not regenerated. Conversely, naive CD8(+) cells were normal. After an initial recovery, lymphocyte proliferation to mitogens progressively declined compared with controls and genotypically identical donor cells grown in the WHN(+/-) environment. Analysis of the T-cell receptor (TCR) repertoire of CD4(+) cells revealed that only 3 of 18 Vbeta families had an altered CDR3 heterogeneity length profile. Conversely, CD8(+) lymphocytes showed an abnormal distribution in most Vbeta families. These data indicate that the thymus is differentially required in the reconstitution of CD4(+) and CD8(+) naive subsets and in the maintenance of their TCR repertoire complexity. Taken together, these findings suggest that bone marrow transplantation is ineffective in the long-term cure of this form of SCID.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11159512&dopt=Abstract

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