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Am J Kidney Dis. 2001 Jan;37(1):E9.
Alopecia in three women of Southeast Asian descent with chronic renal failure: possible association with erythropoietin use.

Whitwam W, Lewis M, Rabb H.

Department of Medicine, Hennepin County Medical Center & University of Minnesota, Minneapolis, MN 55415, USA.

Recombinant human erythropoietin (Epo) has been used successfully to correct the anemia caused by chronic renal failure in patients undergoing dialysis, as well as the anemia associated with other conditions, including cancer therapy. Despite its benefits, it can be associated with adverse side effects. These include hypertension, headaches, increased seizure activity, clotted vascular access, and occasional thromboembolic events, such as myocardial infarction or stroke. We report a potentially new side effect associated with Epo of a cosmetic nature. Three Southeast Asian women with chronic renal failure developed diffuse, nearly total, hair loss during erythropoietin use. Two cases were strongly associated with Epo use, and a third had other intercurrent illnesses as well. Alopecia may be associated with Epo use in certain ethnic populations.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11136198&dopt=Abstract

Cutis. 2000 Dec;66(6):420-4.
Cutaneous aspects of Down syndrome.

Dourmishev A, Miteva L, Mitev V, Pramatarov K, Schwartz RA.

Department of Dermatology and Venereology Biochemistry, Medical University, Sofia, Bulgaria.

Down syndrome is associated with an increased incidence of cutaneous manifestations such as atopic dermatitis, alopecia areata, elastosis perforans serpiginosa, syringomas, and skin infections. We describe 3 patients with Down syndrome: an 8-year-old boy with alopecia areata, a 17-year-old boy with crusted scabies, and a 39-year-old woman with a cutaneous collagen vascular disease-like disorder. We also review cutaneous signs of this syndrome.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11138359&dopt=Abstract

Ann Otol Rhinol Laryngol Suppl. 2000 Dec;185:23-5.
Shaw scalpel in revision cochlear implant surgery.

Roland JT Jr, Fishman AJ, Waltzman SB, Cohen NL.

Department of Otolaryngology, New York University School of Medicine, New York, USA.

The use of traditional electrocautery is prohibited in revision or replacement cochlear implant surgery because of the concern for end organ tissue damage. Additionally, electrical current spread to the malfunctioning device could interfere with an accurate cause-of-failure analysis. Clinical reports have confirmed the utility of the Shaw scalpel for dermatologic, ophthalmic, and head and neck surgery. The Shaw scalpel is a thermally activated cutting blade that provides a bloodless field through immediate capillary and small vessel hemostasis. Avoidance of wound and flap complications is of primary concern in cochlear implant surgery. The long-term wound healing compared favorably to that of other surgical cutting instruments in several experimental reports. We have routinely used the Shaw scalpel in revision cochlear implant surgery and in primary surgery whenever electrocautery was contraindicated. We have retrospectively evaluated 22 cases in which the Shaw scalpel was used for cochlear implant revision and primary surgery. The chart review included patient demographics, the indication for surgery, the contraindication for electrocautery, intraoperative surgical notes, the wound healing evaluation, the evaluation for alopecia, and postoperative speech understanding. No significant complications occurred intraoperatively, and the long-term wound healing results were no different from those obtained with conventional surgical techniques. The explanted devices were undamaged, and valuable diagnostic information could be obtained. All patients performed at or better than their preoperative levels on speech recognition testing. Our results indicate that the Shaw scalpel is a relatively safe, easy-to-use, and effective instrument.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11140990&dopt=Abstract

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