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Alopecia, hair loss abstracts ||
Kurume Med J. 2000;47(3):193-7.
Anticancer drugs induce apoptosis in mouse hair follicles.
Mori O, Matsuo K, Hashimoto T.
Department of Dermatology, Kurume University School of Medicine, Japan.
Apoptosis represents an important mode of cell death induced by chemotherapeutic drugs. It is plausible that apoptosis may also play an important role in alopecia caused by anticancer drugs. C57 BL/6 mice were induced to enter into anagen by hair shaft depilation and a single intraperitoneal injection of cyclophosphamide (150 mg/kg) was given. Skin specimens were taken from the backs of mice at day 9, 10, 11, 12 and 13 postdepilation (p.d.). Specimens were stained with TUNEL method, and DNA was isolated from the plucked hair follicles and was electrophoresed. Many TUNEL-positive cells were observed in hair bulbs in the cyclophosphamide group at days 10-13. At day 13 p.d., most follicles were damaged and extensive hair loss was observed. Fragmented DNA, but not so distinct, were observed in a DNA ladder pattern corresponding to the in situ results. This study suggests that anticancer drugs can induce apoptosis-related damage to the hair follicles in mice. Control mice when treated with saline also showed apoptosis when they spontaneously entered into catagen, but they never showed hair loss. Consequently, hair loss induced by anticancer drugs may result from a wave of induced apoptotic death.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11059219&dopt=Abstract
Oncol Nurs Forum. 1999 Oct;26(9):1463-8.
A narrative study of chemotherapy-induced alopecia.
Williams J, Wood C, Cunningham-Warburton P.
Rhode Island College, Providence, USA. jwilliamic.edu
PURPOSE/OBJECTIVES: To describe the experience of alopecia in people undergoing chemotherapy. DESIGN: Qualitative. SAMPLE: Using announcement flyers, 15 participants (13 women and 2 men) were recruited to participate in audiotaped, in-depth interviews. METHOD: In-depth interviews and narrative analysis of participants' "stories" using a sociolinguistic approach to narrative analysis. FINDINGS: Alopecia is a significant and disturbing side effect of chemotherapy. Preparing for hair loss, experiencing hair falling out, realizing an altered sense of self, trying to look normal, being reminded of disease, joking about alopecia, sharing being bald, having problems with wigs, taking control, and experiencing hair growing back emerged as aspects of the experience. CONCLUSIONS: Understanding the full significance of the experience of alopecia in an individual's everyday life and personal identity is critical to providing support during the course of illness and developing strategies to help clients cope with the difficult changes that occur during cancer treatment. IMPLICATIONS FOR NURSING PRACTICE: Information about alopecia can help to cognitively prepare the person, but the emotional response to alopecia is difficult to anticipate. Nurses need to create an atmosphere that encourages patients to tell their stories.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11064878&dopt=Abstract
Br J Dermatol. 2000 Nov;143(5):1032-5.
Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata.
Bissonnette R, Shapiro J, Zeng H, McLean DI, Lui H.
Division of Dermatology, Vancouver General Hospital and University of British Columbia, 835 West 10th Avenue, Vancouver, BC V5Z 4E8, Canada.
BACKGROUND: Photodynamic therapy (PDT) is a new modality involving the administration of a photosensitizer, or photosensitizer precursor, followed by its activation with light to generate a therapeutic effect. 5-Aminolaevulinic acid (ALA) is a photosensitizer precursor that is transformed by cells into protoporphyrin IX (PpIX), which can in turn be activated by red light. OBJECTIVES: To investigate the effect of PDT in alopecia areata (AA). METHODS: In six patients with extensive AA, topical ALA lotion at 5%, 10% and 20% as well as the vehicle lotion alone were applied separately to different scalp areas, followed 3 h later by exposure to red light at each treatment session. RESULTS: No significant hair growth was observed after 20 twice-weekly treatment sessions. A significant increase in erythema and pigmentation was observed for the three concentrations of ALA lotion vs. the vehicle, implying that a phototoxic PDT effect was achieved in the skin. In vivo fluorescence spectroscopy in one patient showed an increase in red PpIX fluorescence 3 h after ALA application followed by a decrease after light exposure. On fluorescence microscopy, bright red fluorescence was present in the epidermis and sebaceous glands, but not in the inflammatory infiltrate surrounding the hair follicle following ALA application. CONCLUSIONS: PDT was ineffective in the treatment of AA.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11069515&dopt=Abstract
Hair growth is a complex biological process, which has not yet been completely understood. A multitude of therapeutic measures, including drugs, surgery, and suppelements have been made available, and used. However, due to the diversity of the problems underlying hair loss, there is no single solution for all hair loss cases. Most of chemical drugs and hair transplantation surgeries are not free from varying degrees of undesirable side effects on health.
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